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Microparticles from human the lower airway show inhibitory activity against respiratory syncytial virus

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Abstract

Airway microparticles (MPs) have been shown previously to inhibit influenza virus by trapping virions on their surface through their surface viral receptor. It was hypothesized that airway MPs may carry most of the epithelial cell surface molecules, including receptors for respiratory viruses, and may be able to inhibit various respiratory viruses. We show here that MPs from human bronchoalveolar lavage (BAL) can inhibit respiratory syncytial virus (RSV). Those MPs stained positive for the RSV receptor, CX3CR1. Furthermore, incubating the MPs with a monoclonal antibody against CX3CR1 reduced the anti-RSV activity. These data indicate that MPs can contribute to respiratory innate antiviral defense.

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Acknowledgments

This study was supported by a research grant from the National Research Council of Thailand and partly supported by the Faculty of Medicine Siriraj Hospital, Mahidol University. We would like to thank Disayabutr S. and Ahussabhumi J. for clinical assistance in BAL sample collection.

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Authors and Affiliations

  1. Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand

    Chompunuch Boonarkart, Kanyarat Ruangrung & Prasert Auewarakul

  2. Faculty of Medicine and Public Health, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand

    Ornpreya Suptawiwat

  3. Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

    Kittipong Maneechotesuwan

Authors
  1. Chompunuch Boonarkart
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  2. Ornpreya Suptawiwat
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  3. Kanyarat Ruangrung
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  4. Kittipong Maneechotesuwan
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  5. Prasert Auewarakul
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Correspondence to Prasert Auewarakul.

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Boonarkart, C., Suptawiwat, O., Ruangrung, K. et al. Microparticles from human the lower airway show inhibitory activity against respiratory syncytial virus. Arch Virol 166, 2579–2584 (2021). https://doi.org/10.1007/s00705-021-05144-5

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  • DOI: https://doi.org/10.1007/s00705-021-05144-5

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