Skip to main content

Advertisement

SpringerLink
Log in

Correlation between IL-28 polymorphism and spontaneous clearance in HCV patients: systematic review and meta-analysis

  • Original Article
  • Published:
Archives of Virology Aims and scope Submit manuscript

Abstract

Hepatitis C virus (HCV) is a serious global health issue. Nearly 20% of HCV patients spontaneously clear the virus. While some studies have shown an association of spontaneous clearance (SC) of the virus with interleukin (IL) 28B single-nucleotide polymorphisms (SNPs), others did not show such a relationship. Thus, the purpose of the present study was to investigate the association of IL28B polymorphisms (12979860 SNP) with SC of HCV infection. Upon initial screening of the databases, a total of 545 articles were retrieved, of which 22 studies that met predefined eligibility criteria were entered into the meta-analysis. Odds ratios (ORs) with confidence intervals (95% CI), heterogeneity, publication bias, and sensitivity analysis were assessed. According to the meta-analysis results, a significant association was observed between the rs12979860 SNP and SC of HCV infection. The results indicated that the ORs of SC from hepatitis C virus infection were 2.75 times higher in those with cytokine gene polymorphisms (95% CI, 2.23 to 3.38). Moreover, it was found that the prevalence of rs12979860 CC was 0.33 with 95 CI 0.28-0.38 in genotype 1 and was 0.40 with 95 CI 0.34-0.47 in other genotypes. Our meta-analysis results suggest that IL28B rs12979860 CC is a strong predictor for SC of hepatitis C infection in PEG IFN-a/RBV-treated patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Mohamed AA, Elbedewy TA, El-Serafy M, El-Toukhy N, Ahmed W, El Din ZA (2015) Hepatitis C virus: a global view. World J Hepatol 7(26):2676

    Article  PubMed  PubMed Central  Google Scholar 

  2. Mohd Hanafiah K, Groeger J, Flaxman AD, Wiersma ST (2013) Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence. Hepatology 57(4):1333–1342

    Article  PubMed  Google Scholar 

  3. Petruzziello A, Marigliano S, Loquercio G, Cozzolino A, Cacciapuoti C (2016) Global epidemiology of hepatitis C virus infection: an up-date of the distribution and circulation of hepatitis C virus genotypes. World J Gastroenterol 22(34):7824

    Article  PubMed  PubMed Central  Google Scholar 

  4. Jiménez-Sousa MA, Fernández-Rodríguez A, Guzmán-Fulgencio M, García-Álvarez M, Resino S (2013) Meta-analysis: implications of interleukin-28B polymorphisms in spontaneous and treatment-related clearance for patients with hepatitis C. BMC Med 11(1):6

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  5. Micallef J, Kaldor J, Dore G (2006) Spontaneous viral clearance following acute hepatitis C infection: a systematic review of longitudinal studies. J Viral Hepat 13(1):34–41

    Article  CAS  PubMed  Google Scholar 

  6. Chuang W-L, Yu M-L (2013) Host factors determining the efficacy of hepatitis C treatment. J Gastroenterol 48(1):22–30

    Article  CAS  PubMed  Google Scholar 

  7. Georgel P, Schuster C, Zeisel MB, Stoll-Keller F, Berg T, Bahram S, Baumert TF (2010) Virus–host interactions in hepatitis C virus infection: implications for molecular pathogenesis and antiviral strategies. Trends Mol Med 16(6):277–286

    Article  CAS  PubMed  Google Scholar 

  8. Lloyd AR, Jagger E, Post JJ, Crooks LA, Rawlinson WD, Hahn YS, Ffrench RA (2007) Host and viral factors in the immunopathogenesis of primary hepatitis C virus infection. Immunol Cell Biol 85(1):24–32

    Article  CAS  PubMed  Google Scholar 

  9. Arends JE, Fransen JH, Hoepelman AI, van Baarle D (2011) Association between IL28B polymorphisms and first-phase viral load decrease in chronic hepatitis C virus-infected patients treated with peginterferon alfa-2b/ribavirin. Int J Antimicrob Agents 38(6):538–539

    Article  CAS  PubMed  Google Scholar 

  10. Mizokami M (2012) Discovery of critical host factor, IL-28B, associated with response to hepatitis C virus treatment. J Gastroenterol Hepatol 27(3):425–429

    Article  CAS  PubMed  Google Scholar 

  11. Kim SU, Song KJ, Chang HY, Shin E-C, Park JY, Han K-H, Chon CY, Ahn SH (2013) Association between IL28B polymorphisms and spontaneous clearance of hepatitis B virus infection. PLoS ONE 8(7):e69166

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Marcello T, Grakoui A, Barba-Spaeth G, Machlin ES, Kotenko SV, Macdonald MR, Rice CM (2006) Interferons α and λ inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics. Gastroenterology 131(6):1887–1898

    Article  PubMed  Google Scholar 

  13. Pagliaccetti NE, Robek MD (2010) Interferon-λ in HCV infection and therapy. Viruses 2(8):1589–1602

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Berger CT, Kim AY (2012) IL28B polymorphisms as a pretreatment predictor of response to HCV treatment. Infect Dis Clin 26(4):863–877

    Article  Google Scholar 

  15. Neumann U (2011) Impact of IL-28B polymorphism on outcome in patients with hepatitis C after liver transplantation. Expert Rev Gastroenterol Hepatol 5(4):429–431

    Article  CAS  PubMed  Google Scholar 

  16. Sulkowski M, Rodriguez-Torres M, Lawitz E, Shiffman M, Pol S, Herring R, McHutchison J, Pang P, Brainard D, Wyles D (2012) 1421 high sustained virologic response rate in treatment-naive HCV genotype 1a and 1b patients treated for 12 weeks with an interferon-free all-oral quad regimen: interim results. J Hepatol 56:S560

    Google Scholar 

  17. Chen T-Y, Hsieh Y-S, Wu T-T, Yang S-F, Wu C-J, Tsay GJ, Chiou H-L (2007) Impact of serum levels and gene polymorphism of cytokines on chronic hepatitis C infection. Transl Res 150(2):116–121

    Article  CAS  PubMed  Google Scholar 

  18. Li S, Hu P, Zhang Q-Q, Liu Y-H, Hu H-D, Zhang D-Z, Ren H (2011) Single nucleotide polymorphisms of the IL28B and sustained virologic response of patients with chronic hepatitis C to PEG-interferon/ribavirin therapy: a meta-analysis: meta-analysis of IL28B. Hepat Mon 11(3):163

    CAS  PubMed  PubMed Central  Google Scholar 

  19. Ramos JA, Silva R, Hoffmann L, Ramos ALA, Cabello PH, Ürményi TP, Villella-Nogueira CA, Lewis-Ximenez L, Rondinelli EJB (2012) Association of IL-10, IL-4, and IL-28B gene polymorphisms with spontaneous clearance of hepatitis C virus in a population from Rio de Janeiro. BMC Res 5(1):508

    Article  CAS  Google Scholar 

  20. Schreiber J, Moreno C, Garcia BG, Louvet A, Trepo E, Henrion J, Thabut D, Mathurin P, Deltenre P (2012) Meta-analysis: the impact of IL 28 B polymorphisms on rapid and sustained virological response in HCV-2 and-3 patients. Aliment Pharmacol Ther 36(4):353–362

    Article  CAS  PubMed  Google Scholar 

  21. Shi K-Q, Liu W-Y, Lin X-F, Fan Y-C, Chen Y-P, Zheng M-H (2012) Interleukin-28B polymorphisms on the SVR in the treatment of naive chronic hepatitis C with pegylated interferon-α plus ribavirin: a meta-analysis. Gene 507(1):27–35

    Article  CAS  PubMed  Google Scholar 

  22. Hashem M, Jhaveri R, DaA S, Sharaf SA, El-Mougy F, Abdelsalam L, Shardell MD, El-Ghazaly H, El-Kamary SSJCID (2017) Spontaneous viral load decline and subsequent clearance of chronic hepatitis C virus in postpartum women correlates with favorable interleukin-28B gene allele. Clin Infect Dis 65(6):999–1005

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Sarvari J, Mansouri M, Hashempoor T, Hosseini SY, Moattari A, Pirbonyeh N, Dowran R, Moayedi J, Musavi Z, Fattahi M-RJHM (2017) Association of genotype and haplotype of IL-28B Gene with Hepatitis C infection outcome in Iran: spontaneous clearance versus chronic infection. Hepat Mon 17 (5)

  24. Falleti E, Bitetto D, Fabris C, Cussigh A, Fornasiere E, Cmet S, Fumolo E, Bignulin S, Fontanini E, Cerutti AJ (2011) Role of interleukin 28B rs12979860 C/T polymorphism on the histological outcome of chronic hepatitis C: relationship with gender and viral genotype. J Clin Immunol 31(5):891–899

    Article  CAS  PubMed  Google Scholar 

  25. Grebely J, Page K, Sacks-Davis R, van der Loeff MS, Rice TM, Bruneau J, Morris MD, Hajarizadeh B, Amin J, Cox ALJH (2014) The effects of female sex, viral genotype, and IL28B genotype on spontaneous clearance of acute hepatitis C virus infection. Hepatology 59(1):109–120

    Article  CAS  PubMed  Google Scholar 

  26. Carapito R, Poustchi H, Kwemou M, Untrau M, Sharifi A, Merat S, Haj-Sheykholeslami A, Jabbari H, Esmaili S, Michel SJG (2015) Polymorphisms in EGFR and IL28B are associated with spontaneous clearance in an HCV-infected Iranian population. Immunity 16(8):514–518

    Article  CAS  Google Scholar 

  27. Indolfi G, Mangone G, Bartolini E, Nebbia G, Calvo PL, Moriondo M, Tovo P-A, De Martino M, Azzari C, Resti MJ (2014) Comparative analysis of rs12979860 SNP of the IFNL3 gene in children with hepatitis C and ethnic matched controls using 1000 Genomes Project data. PLoS ONE 9(1):e85899

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  28. Knapp S, Warshow U, Ho KA, Hegazy D, Little AM, Fowell A, Alexander G, Thursz M, Cramp M, Khakoo SI (2011) A polymorphism in IL28B distinguishes exposed, uninfected individuals from spontaneous resolvers of HCV infection. Gastroenterology 141(1):320–325 (e322)

    Article  CAS  PubMed  Google Scholar 

  29. Ezzikouri S, Alaoui R, Rebbani K, Brahim I, Fakhir F-Z, Nadir S, Diepolder H, Khakoo SI, Thursz M, Benjelloun SJ (2013) Genetic variation in the interleukin-28B gene is associated with spontaneous clearance and progression of hepatitis C virus in Moroccan patients. PLoS ONE 8(1):e54793

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Indolfi G, Mangone G, Calvo PL, Bartolini E, Regoli M, Serranti D, Calitri C, Tovo P-A, de Martino M, Azzari CJ (2014) Interleukin 28B rs12979860 single-nucleotide polymorphism predicts spontaneous clearance of hepatitis C virus in children. J Pediatr Gastroenterol Nutr 58(5):666–668

    Article  CAS  PubMed  Google Scholar 

  31. Kurbanov F, Abdel-Hamid M, Latanich R, Astemborski J, Mohamed M, Mikhail NM, El-Daly M, El-Kafrawy S, Thomas DL, Thio CL (2011) Genetic polymorphism in IL28B is associated with spontaneous clearance of hepatitis C virus genotype 4 infection in an Egyptian cohort. J Infect Dis 204(9):1391–1394

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Knapp S, Zakaria Z, Hashem M, Zaghla H, Khakoo SI, Waked I, Thursz M, Abdelwahab SF (2015) Influence of IFNL3. rs12979860 and IFNL4. ss469415590 polymorphism on clearance of hepatitis C virus infection among Egyptians. Hepatol Int 9(2):251–257

    Article  PubMed  Google Scholar 

  33. Fabrício-Silva GM, Poschetzky BS, de Mello PR, dos Santos RC, Cavalini LT, Porto LC (2015) Association of cytokine gene polymorphisms with hepatitis C virus infection in a population from Rio de Janeiro, Brazil. Hepat Med Evid Res 7:71

    Google Scholar 

  34. Shebl FM, Pfeiffer RM, Buckett D, Muchmore B, Chen S, Dotrang M, Prokunina-Olsson L, Edlin BR, O’Brien TR (2011) IL28B rs12979860 genotype and spontaneous clearance of hepatitis C virus in a multi-ethnic cohort of injection drug users: evidence for a supra-additive association. J Infect Dis 204(12):1843–1847

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Sharafi H, Alavian SM, Behnava B, Pouryasin A, Keshvari MJ (2014) The impact of IFNL4 rs12979860 polymorphism on spontaneous clearance of hepatitis C; a case-control study. Hepat Mon 14(10)

  36. Laird ME, Mohsen A, Duffy D, Mamdouh R, LeFouler L, Casrouge A, El-Daly M, Rafik M, Abdel-Hamid M, Soulier AJ (2014) Apolipoprotein H expression is associated with IL28B genotype and viral clearance in hepatitis C virus infection. J Hepatol 61(4):770–776

    Article  CAS  PubMed  Google Scholar 

  37. Nattermann J, Timm J, Nischalke HD, Olbrich A, Michalk M, Tillmann HL, Berg T, Wedemeyer H, Tenckhoff H, Wiese MJ (2011) The predictive value of IL28B gene polymorphism for spontaneous clearance in a single source outbreak cohort is limited in patients carrying the CCR5Δ32 mutation. J Hepatol 55(6):1201–1206

    Article  CAS  PubMed  Google Scholar 

  38. Spada E, Amoroso P, Taliani G, Zuccaro O, Chiriacò P, Maio P, Maio G, Esposito ML, Mariano C, Rinaldi RJ (2013) Role of IL28B gene polymorphism and cell-mediated immunity in spontaneous resolution of acute hepatitis C. Clin Infect Dis 57(6):803–811

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Wu R-R, Liu F-Q, Zhu S-S, Han JJ (2014) Association of hepatitis C virus infection and interleukin-28B gene polymorphism in Chinese children. Pak J Med Sci 30(3):519

    PubMed  PubMed Central  Google Scholar 

  40. Ruiz-Extremera Á, Muñoz-Gámez JA, Salmerón-Ruiz MA, de Rueda PM, Quiles-Pérez R, Gila-Medina A, Casado J, Belén Martín A, Sanjuan-Nuñez L, Carazo AJ (2011) Genetic variation in interleukin 28B with respect to vertical transmission of hepatitis C virus and spontaneous clearance in HCV-infected children. Hepatology 53(6):1830–1838

    Article  CAS  PubMed  Google Scholar 

  41. Pedergnana V, Abdel-Hamid M, Guergnon J, Mohsen A, Le Fouler L, Theodorou I, Mohamed MK, Fontanet A, Plancoulaine S, Abel LJ (2012) Analysis of IL28B variants in an Egyptian population defines the 20 kilobases minimal region involved in spontaneous clearance of hepatitis C virus. PLoS ONE 7(6):e38578

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Gonzalez-Aldaco K, Rebello Pinho JR, Roman S, Gleyzer K, Fierro NA, Oyakawa L, Ramos-Lopez O, Ferraz Santana RA, Sitnik R, Panduro AJ (2016) Association with spontaneous hepatitis C viral clearance and genetic differentiation of IL28B/IFNL4 haplotypes in populations from Mexico. PLoS ONE 11(1):e0146258

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  43. Hashem M, Zaghla H, Zakaria Z, Allam WR, Sameea EA, Mikhail NN, Sobhy M, Galal IF, Mokhtar Y, Hamdy SJ (2018) High spontaneous clearance of symptomatic iatrogenic acute hepatitis C genotype 4 infection. J Med Virol 90(12):1841–1847

    Article  CAS  PubMed  Google Scholar 

  44. Abdelwahab SF, Zakaria Z, Allam WR, Hamdy S, Mahmoud MA, Sobhy M, Rewisha E, Waked IJ (2015) Interleukin 28B rs12979860 genotype does not affect hepatitis C viral load in Egyptians with genotype 4 chronic infection. Arch Virol 160(11):2833–2837

    Article  CAS  PubMed  Google Scholar 

  45. Blazer DG, Hernandez LM (2006) Genes, behavior, and the social environment: Moving beyond the nature/nurture debate. National Academies Press, Washington, DC

    Google Scholar 

  46. Cariani E, Roli L, Missale G, Villa E, Ferrari C, Trenti T (2016) Interleukin 28B polymorphisms as predictors of sustained virological response in chronic hepatitis C: systematic review and meta-analysis. Pharmacogenom J 16(1):18–29

    Article  CAS  Google Scholar 

  47. Balagopal A, Thomas DL, Thio CL (2010) IL28B and the control of hepatitis C virus infection. Gastroenterology 139(6):1865–1876

    Article  CAS  PubMed  Google Scholar 

  48. Zhang L, Jilg N, Shao R-X, Lin W, Fusco DN, Zhao H, Goto K, Peng LF, Chen W-C, Chung RT (2011) IL28B inhibits hepatitis C virus replication through the JAK–STAT pathway. J Hepatol 55(2):289–298

    Article  CAS  PubMed  Google Scholar 

  49. Moghaddam A, Melum E, Reinton N, Ring-Larsen H, Verbaan H, Bjøro K, Dalgard O (2011) IL28B genetic variation and treatment response in patients with hepatitis C virus genotype 3 infection. Hepatology 53(3):746–754

    Article  CAS  PubMed  Google Scholar 

  50. Patel K, Lucas JE, Thompson JW, Dubois LG, Tillmann HL, Thompson AJ, Uzarski D, Califf RM, Moseley MA, Ginsburg GS (2011) High predictive accuracy of an unbiased proteomic profile for sustained virologic response in chronic hepatitis C patients. Hepatology 53(6):1809–1818

    Article  CAS  PubMed  Google Scholar 

  51. Venegas M, Villanueva RA, González K, Brahm J (2011) IL28B polymorphisms associated with therapy response in Chilean chronic hepatitis C patients. World J Gastroenterol: WJG 17(31):3636

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Zhou J-h, Wang Y-n, Chang Q-y, Ma P, Hu Y, Cao X (2018) Type III interferons in viral infection and antiviral immunity. Cell Physiol Biochem 51(1):173–185

    Article  CAS  PubMed  Google Scholar 

  53. Grebely J, Prins M, Hellard M, Cox AL, Osburn WO, Lauer G, Page K, Lloyd AR, Dore GJ (2012) Hepatitis C virus clearance, reinfection, and persistence, with insights from studies of injecting drug users: towards a vaccine. Lancet Infect Dis 12(5):408–414

    Article  PubMed  PubMed Central  Google Scholar 

  54. Thomas DL, Thio CL, Martin MP, Qi Y, Ge D, Ohuigin C, Kidd J, Kidd K, Khakoo SI, Alexander G (2009) Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 461(7265):798–801

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Suppiah V, Moldovan M, Ahlenstiel G, Berg T, Weltman M, Abate ML, Bassendine M, Spengler U, Dore GJ, Powell E (2009) IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy. Nat Genet 41(10):1100

    Article  CAS  PubMed  Google Scholar 

  56. Tanaka Y, Nishida N, Sugiyama M, Kurosaki M, Matsuura K, Sakamoto N, Nakagawa M, Korenaga M, Hino K, Hige S (2009) Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C. Nat Genet 41(10):1105

    Article  CAS  PubMed  Google Scholar 

  57. Thio CL (2008) Host genetic factors and antiviral immune responses to hepatitis C virus. Clin Liver Dis 12(3):713–726

    Article  PubMed  PubMed Central  Google Scholar 

  58. Younossi ZM, Baranova A, Afendy A, Collantes R, Stepanova M, Manyam G, Bakshi A, Sigua CL, Chan JP, Iverson AA (2009) Early gene expression profiles of patients with chronic hepatitis C treated with pegylated interferon-alfa and ribavirin. Hepatology 49(3):763–774

    Article  CAS  PubMed  Google Scholar 

  59. Falleti E, Bitetto D, Fabris C, Cussigh A, Fornasiere E, Cmet S, Fumolo E, Bignulin S, Fontanini E, Cerutti A, Minisini R, Pirisi M, Toniutto P (2011) Role of interleukin 28B rs12979860 C/T polymorphism on the histological outcome of chronic hepatitis C: relationship with gender and viral genotype. J Clin Immunol 31(5):891–899. https://doi.org/10.1007/s10875-011-9547-1

    Article  CAS  PubMed  Google Scholar 

  60. Carapito R, Poustchi H, Kwemou M, Untrau M, Sharifi AH, Merat S, Haj-Sheykholeslami A, Jabbari H, Esmaili S, Michel S, Toussaint J, Le Gentil M, Ansari-Moghaddam A, Radosavljevic M, Etemadi A, Georgel P, Malekzadeh R, Bahram S (2015) Polymorphisms in EGFR and IL28B are associated with spontaneous clearance in an HCV-infected Iranian population. Genes Immun 16(8):514–518. https://doi.org/10.1038/gene.2015.38

    Article  CAS  PubMed  Google Scholar 

  61. Indolfi G, Mangone G, Bartolini E, Nebbia G, Calvo PL, Moriondo M, Tovo PA, de Martino M, Azzari C, Resti M (2014) Comparative analysis of rs12979860 SNP of the IFNL3 gene in children with hepatitis C and ethnic matched controls using 1000 Genomes Project data. PLoS ONE 9(1):e85899. https://doi.org/10.1371/journal.pone.0085899

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Gonzalez-Aldaco K, Rebello Pinho JR, Roman S, Gleyzer K, Fierro NA, Oyakawa L, Ramos-Lopez O, Ferraz Santana RA, Sitnik R, Panduro A (2016) Association with Spontaneous Hepatitis C Viral Clearance and Genetic Differentiation of IL28B/IFNL4 Haplotypes in Populations from Mexico. PLoS ONE 11(1):e0146258. https://doi.org/10.1371/journal.pone.0146258

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. Indolfi G, Mangone G, Calvo PL, Bartolini E, Regoli M, Serranti D, Calitri C, Tovo PA, de Martino M, Azzari C, Resti M (2014) Interleukin 28B rs12979860 single-nucleotide polymorphism predicts spontaneous clearance of hepatitis C virus in children. J Pediatr Gastroenterol Nutr 58(5):666–668. https://doi.org/10.1097/mpg.0000000000000275

    Article  CAS  PubMed  Google Scholar 

  64. Knapp S, Zakaria Z, Hashem M, Zaghla H, Khakoo SI, Waked I, Thursz M, Abdelwahab SF (2015) Influence of IFNL3.rs12979860 and IFNL4.ss469415590 polymorphism on clearance of hepatitis C virus infection among Egyptians. Hepatol Int 9(2):251–257. https://doi.org/10.1007/s12072-015-9619-z

    Article  PubMed  Google Scholar 

  65. Fabricio-Silva GM, Poschetzky BS, de Mello PR, Dos Santos RC, Cavalini LT, Porto LC (2015) Association of cytokine gene polymorphisms with hepatitis C virus infection in a population from Rio de Janeiro, Brazil. Hepat Med 7:71–79. https://doi.org/10.2147/hmer.S89447

    Article  PubMed  PubMed Central  Google Scholar 

  66. Laird ME, Mohsen A, Duffy D, Mamdouh R, LeFouler L, Casrouge A, El-Daly M, Rafik M, Abdel-Hamid M, Soulier A, Pawlotsky JM, Hezode C, Rosa I, Renard P, Mohamed MK, Bonnard P, Izopet J, Mallet V, Pol S, Albert ML, Fontanet A (2014) Apolipoprotein H expression is associated with IL28B genotype and viral clearance in hepatitis C virus infection. J Hepatol 61(4):770–776. https://doi.org/10.1016/j.jhep.2014.05.040

    Article  CAS  PubMed  Google Scholar 

  67. Nattermann J, Timm J, Nischalke HD, Olbrich A, Michalk M, Tillmann HL, Berg T, Wedemeyer H, Tenckhoff H, Wiese M, Kullig U, Gobel U, Capka E, Schiefke I, Guthof W, Grungreiff K, Konig I, Roggendorf M, Sauerbruch T, Spengler U (2011) The predictive value of IL28B gene polymorphism for spontaneous clearance in a single source outbreak cohort is limited in patients carrying the CCR5Delta32 mutation. J Hepatol 55(6):1201–1206. https://doi.org/10.1016/j.jhep.2011.03.011

    Article  CAS  PubMed  Google Scholar 

  68. Spada E, Amoroso P, Taliani G, Zuccaro O, Chiriaco P, Maio P, Maio G, Esposito ML, Mariano C, Rinaldi R, Bellissima P, Tosti ME, Del Porto P, Francavilla R, Mellace V, Garbuglia AR, Folgori A, Mele A (2013) Role of IL28B gene polymorphism and cell-mediated immunity in spontaneous resolution of acute hepatitis C. Clin Infect Dis 57(6):803–811. https://doi.org/10.1093/cid/cit402

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  69. Ruiz-Extremera A, Munoz-Gamez JA, Salmeron-Ruiz MA, de Rueda PM, Quiles-Perez R, Gila-Medina A, Casado J, Belen Martin A, Sanjuan-Nunez L, Carazo A, Pavon EJ, Ocete-Hita E, Leon J, Salmeron J (2011) Genetic variation in interleukin 28B with respect to vertical transmission of hepatitis C virus and spontaneous clearance in HCV-infected children. Hepatology 53(6):1830–1838. https://doi.org/10.1002/hep.24298

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This work was supported by a grant from Shiraz University of Medical Sciences (no. 15969).

Funding

Shiraz University of Medical Sciences, Grant/Award Number: 19569.

Author information

Authors and Affiliations

  1. Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Hamid Heidarian Miri

  2. Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, 7134845794, Shiraz, Iran

    Pooria Fazeli & Kurosh Kalantar

  3. Department of Immunology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran

    Mohammad Ali-Hassanzadeh

  4. Institute of Immunology, University of Kiel, Kiel, Germany

    Dieter Kabelitz

  5. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

    Peyman Bemani

Authors
  1. Hamid Heidarian Miri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pooria Fazeli
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mohammad Ali-Hassanzadeh
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Peyman Bemani
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Dieter Kabelitz
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kurosh Kalantar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kurosh Kalantar.

Ethics declarations

Conflict of interest

All authors declare they have no conflicts of interest.

Ethical approval

This is an observational study. The Shiraz University of Medical Sciences Research Ethics Committee has confirmed that no ethical approval is required.

Additional information

Handling Editor: Michael A. Purdy.

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Miri, H.H., Fazeli, P., Ali-Hassanzadeh, M. et al. Correlation between IL-28 polymorphism and spontaneous clearance in HCV patients: systematic review and meta-analysis. Arch Virol 166, 2469–2478 (2021). https://doi.org/10.1007/s00705-021-05141-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00705-021-05141-8

Search

Navigation