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Host genetic polymorphisms associated with beta human papillomavirus seropositivity

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Abstract

Human papillomaviruses (HPVs) cause superficial epidermal infections and are only cleared if they trigger an immunological response. We analysed SNPs that had previously been investigated for association with HPV infection to determine whether they play a role in the serological response to cutaneous beta-HPVs in an Australian population. Serum samples from 1,142 participants were analysed for seropositivity against the L1 protein of 21 beta-HPV types. Associations between seropositivity to beta-HPV types and the SNPs rs9264942 (HLA-C; HPV-9, p = 0.022, HPV-15, p = 0.043 and HPV-17, p = 0.004), rs12449858 (EVER1; HPV-23, p = 0.029), and rs2981451 (FGFR2; HPV-22, p = 0.049) were identified. We found that certain SNPs could be involved in the serological response to beta-HPVs.

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Acknowledgements

We would like to thank all participants of the Nambour Skin Cancer Study. We thank Prof Lyn Griffiths, Ms Rebecca Grealy, and Griffith University for their invaluable contributions to the Nambour Skin Cancer Study DNA resource, including sharing sample processing and storage. We are also grateful to Profs Nick Martin and David Whiteman for their support.

Funding

This work was supported by a Program Grant (1073898) from the National Health and Medical Research Council of Australia (NHMRC). The funding body played no role in the design or conduct of the study. The contents are solely the responsibility of the authors and do not necessarily represent the official views of the funding body.

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Authors and Affiliations

  1. QIMR Berghofer Medical Research Institute, Brisbane, Australia

    Annika Antonsson, Astrid J. Rodriguez-Acevedo, Upekha E. Liyanage, Maria Celia B. Hughes & Adele C. Green

  2. Faculty of Medicine, The University of Queensland, Brisbane, Australia

    Annika Antonsson

  3. School of Exercise and Nutrition Sciences, Queensland University of Technology, Brisbane, Australia

    Jolieke C. van der Pols

  4. CRUK Manchester Institute and Faculty of Biology Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK

    Adele C. Green

Authors
  1. Annika Antonsson
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  2. Astrid J. Rodriguez-Acevedo
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  3. Upekha E. Liyanage
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  4. Maria Celia B. Hughes
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  5. Jolieke C. van der Pols
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  6. Adele C. Green
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Annika Antonsson, Astrid J. Rodriguez-Acevedo, Maria Celia B. Hughes, and Adele C. Green. The first draft of the manuscript was written by Annika Antonsson, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Annika Antonsson.

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The authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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QIMR Berghofer Medical Research Institute’s Human Research Ethics Committee (P327).

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Handling Editor: Carolina Scagnolari.

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Antonsson, A., Rodriguez-Acevedo, A.J., Liyanage, U.E. et al. Host genetic polymorphisms associated with beta human papillomavirus seropositivity. Arch Virol 166, 2569–2572 (2021). https://doi.org/10.1007/s00705-021-05137-4

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  • DOI: https://doi.org/10.1007/s00705-021-05137-4

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