Severe hand, foot, and mouth disease (HFMD) caused by enterovirus 71 (EV71) infection is associated with high mortality and disability. DC-SIGN, a receptor for EV71, is widely distributed in dendritic cells and may influence the severity of HFMD caused by EV71 infection. This observational study attempts to explore whether single-nucleotide polymorphisms (SNPs) in DC-SIGN are related to the severity of EV71-associated HFMD. Based on linkage disequilibrium and functional predictions, two DC-SIGN SNPs were selected and tested to explore their potential association with the severity of HFMD caused by EV71 infection. Two hundred sixteen Han Chinese children with HFMD caused by EV71 were enrolled to obtain clinical data, including the severity of HFMD, serum DC-SIGN levels, and DC-SIGN SNPs. We found a significant association between the rs7248637 polymorphism (A vs. G: OR = 0.644, 95% CI = 0.515-0.806) and the severity of HFMD caused by EV71 infection, as well as the rs4804800 polymorphism (A vs. G: OR = 1.539, 95% CI =1.229-1.928). These two DC-SIGN SNPs may have an effect on the severity of HFMD caused by EV71 infection.
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The authors thank the Medical personnel of the Department of Infectious Diseases of Xi'an Jiaotong University Second Affiliated Hospital and Xi’an Children’s Hospital for their help with sample collection. The authors thank the Centre for Human Genetics Research, Shanghai Genesky Bio-Tech, for technical assistance with genotyping.
This study was funded by National Natural Science Foundation of China, Grant/Award Number 81701632 and Shaanxi Key R&D Program Project, Grant/Award Number 2017ZDXM-SF-071.
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The authors have no conflict of interest to declare.
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This study was approved by the Medical Ethics Committee of Second Affiliated Hospital of Xi'an Jiaotong University and Xi’an Children’s Hospital. Additional informed consent was obtained from all individual participants.
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Li, YP., Wang, MQ., Liu, CR. et al. Polymorphisms in the DC-SIGN gene and their association with the severity of hand, foot, and mouth disease caused by enterovirus 71. Arch Virol 166, 1133–1140 (2021). https://doi.org/10.1007/s00705-021-04991-6