Abstract
An outbreak of chikungunya virus (CHIKV) infection occurred in southwest Bangkok during the 2018 rainy season. The envelope glycoprotein E1 gene sequence of the infecting strain belonged to an East/Central/South African lineage with alanine at residue 226. Mutations in the predicted E1 (K211E) and E2 (V264A) proteins of CHIKV were identified in CHIKV-infected patients and in an Aedes aegypti mosquito. Analysis of the complete genome sequences showed marked differences from the strains causing previous outbreaks in Thailand in 2008-2009 and 2013 but showed similarities to strains from more recent CHIKV outbreaks in South and Southeast Asia.
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Acknowledgements
We thank the staff of Health Center 29 of the Bangkok Health Department. This work was supported by The Research Chair Grant from the National Science and Technology Development Agency (P-15-50004), The Center of Excellence in Clinical Virology of Chulalongkorn University/King Chulalongkorn Memorial Hospital (GCE 59-009-30-005), and Rachadapisek Sompote Fund for Postdoctoral Fellowship, Chulalongkorn University, to Jira Chansaenroj.
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Chansaenroj, J., Wanlapakorn, N., Ngamsaithong, C. et al. Genome sequences of chikungunya virus isolates from an outbreak in southwest Bangkok in 2018. Arch Virol 165, 445–450 (2020). https://doi.org/10.1007/s00705-019-04509-1
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DOI: https://doi.org/10.1007/s00705-019-04509-1