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The complete genome sequence of the lumpy skin disease virus vaccine Herbivac LS reveals a mutation in the superoxide dismutase gene homolog

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Abstract

The lumpy skin disease virus (LSDV) vaccine, Herbivac LS, batch 008, was sequenced and found to differ from the Neethling vaccine strain in the locus encoding a superoxide dismutase (SOD) homolog. The presence of a SOD homolog, be it full-length (as in Herbivac LS) or truncated (as in Neethling) may affect vaccine immunogenicity.

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Acknowledgments

This work was based on the research supported in part by the National Research Foundation of South Africa (grant number 64815) as well as the University of Cape Town (Research Development Grant).

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Author notes

  1. Anelda Van Der Walt

    Present address: Talarify, Registration no 2015/014921/07, PO Box 293, Kleinmond, 7195, South Africa

Authors and Affiliations

  1. Department of Pathology, Institute of Infectious Disease and Molecular Medicine and Division of Medical Virology, University of Cape Town, Observatory, 7925, South Africa

    Nicola Douglass, Ruzaiq Omar, Henry Munyanduki & Anna-Lise Williamson

  2. Central Analytic Facility (CAF), University of Stellenbosch, JC Smuts Building, Van der Bijl Str, Stellenbosch, 7600, South Africa

    Anelda Van Der Walt

Authors
  1. Nicola Douglass
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  2. Anelda Van Der Walt
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  3. Ruzaiq Omar
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  4. Henry Munyanduki
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  5. Anna-Lise Williamson
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Corresponding author

Correspondence to Nicola Douglass.

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Handling Editor: William G Dundon.

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The nucleotide sequence data reported here are available in the GenBank database under the accession number MK441838.

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Douglass, N., Van Der Walt, A., Omar, R. et al. The complete genome sequence of the lumpy skin disease virus vaccine Herbivac LS reveals a mutation in the superoxide dismutase gene homolog. Arch Virol 164, 3107–3109 (2019). https://doi.org/10.1007/s00705-019-04405-8

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  • DOI: https://doi.org/10.1007/s00705-019-04405-8

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