Archives of Virology

, Volume 164, Issue 10, pp 2559–2563 | Cite as

MTTP polymorphisms and hepatic steatosis in individuals chronically infected with hepatitis C virus

  • Thamiris Vaz Gago Prata
  • Dayane de Souza Rodrigues da Silva
  • Caroline Manchiero
  • Bianca Peixoto Dantas
  • Celso Carmo Mazza
  • Arielle Karen da Silva Nunes
  • Edson Abdala
  • Gerusa Maria Figueiredo
  • Fátima Mitiko Tengan
  • Mariana Cavalheiro MagriEmail author
Brief Report


Polymorphisms in the microsomal triglyceride transfer protein (MTTP) gene were genotyped in individuals who were chronically infected with hepatitis C virus (HCV). In the 236 patients, the frequencies of risk alleles of the -164T/C (rs1800804), -400A/T (rs1800803) and H297Q (rs2306985) polymorphisms were 0.30, 0.41 and 0.50, respectively. A significant association between the risk alleles of the -164T/C and -400A/T polymorphisms combined with HCV genotype 3 infection and the occurrence of steatosis was detected (p = 0.004 and p = 0.032), suggesting that a combination of host and viral factors can potentially be used to predict hepatic steatosis.



This study was funded by the Sao Paulo Research Foundation (FAPESP) via grant #2016/19690-5.

Compliance with ethical standards

Conflict of interest

All authors declare no conflict of interest.

Ethical approval

This research received the approval of the Ethics Committee for Research Projects Analysis (CAPPesq) of the Clinical Hospital, School of Medicine, University of Sao Paulo, Brazil, #1.645.384/2016, and was performed according to the Declaration of Helsinki. All data were analyzed anonymously.

Informed consent

The participants involved in this research signed an informed consent statement.

Supplementary material

705_2019_4352_MOESM1_ESM.docx (103 kb)
Supplementary material 1 (DOCX 103 kb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Thamiris Vaz Gago Prata
    • 1
  • Dayane de Souza Rodrigues da Silva
    • 1
  • Caroline Manchiero
    • 1
  • Bianca Peixoto Dantas
    • 1
  • Celso Carmo Mazza
    • 2
  • Arielle Karen da Silva Nunes
    • 1
  • Edson Abdala
    • 2
  • Gerusa Maria Figueiredo
    • 3
  • Fátima Mitiko Tengan
    • 1
    • 2
  • Mariana Cavalheiro Magri
    • 1
    Email author
  1. 1.Laboratorio de Investigacao Medica em Hepatologia por Virus (LIM-47), Hospital das Clinicas HCFMUSP, Faculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil
  2. 2.Departamento de Molestias Infecciosas e Parasitarias, Hospital das Clinicas HCFMUSP, Faculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil
  3. 3.Instituto de Medicina Tropical de Sao PauloUniversidade de Sao PauloSao PauloBrazil

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