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Mumps epidemiology in Cuba between 2004 and 2015

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Abstract

Vaccination with the measles, mumps and rubella vaccine decreased the mumps incidence in Cuba, but in 2006 and 2007 an outbreak with more than 1000 laboratory confirmed cases occurred, mainly among high school and university students. The objective of the study was to investigate mumps epidemiology in Cuba between 2004 and 2015 and provide an in-depth laboratory characterization of selected samples from mumps patients. Samples from 116 cases (throat swabs, urines, paired acute and convalescent serum samples) were tested for mumps-specific IgM antibodies by ELISA, in a hemagglutination inhibition assay (HIA) or by RT-PCR. IgM antibodies were found in 80.2% of cases. 48.3% of first sera were positive, 30 of which were collected within two days after symptom onset. Testing of all 116 paired sera by HIA showed seroconversion in 55.2% individuals and an at least fourfold increase in antibodies in 44.8% of cases. In 18 out of the 111 vaccinated people (16.2%) no IgM antibodies were detected, neither in the acute nor the convalescent sera, but 14 of them showed seroconversion by HIA and 4 had an at least fourfold increase of hemagglutinin antibody titers. In the RT-PCR, 23 acute phase sera, 4 throat swabs and 5 urines were positive. Detection of mumps-specific IgM antibodies by ELISA and additional diagnostic methods may be required in settings with high vaccination coverage rates.

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Acknowledgements

The authors would like to thank the participating staff for reporting and sending samples of mumps cases to be studied in the Reference Laboratory at the Pedro Kouri Institute.

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Authors and Affiliations

  1. National Reference Laboratory of measles, mumps, rubella, Virology Department, Pedro Kourí Institute of Tropical Medicine, Autopista Novia del Mediodía Km 61/2, La Lisa, Marianao 13, P.O. Box 601, Havana, Cuba

    María de los Angeles Ribas, Yahisel Tejero & Yanislet Cordero

  2. Ministry of Health, Havana, Cuba

    Marlen Valcarcel & Miguel Galindo

  3. Infectious Diseases Research Unit, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg

    Aurélie Sausy, Claude P. Muller & Judith M. Hübschen

Authors
  1. María de los Angeles Ribas
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  2. Yahisel Tejero
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  3. Marlen Valcarcel
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  4. Miguel Galindo
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  5. Yanislet Cordero
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  6. Aurélie Sausy
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  7. Claude P. Muller
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  8. Judith M. Hübschen
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Corresponding author

Correspondence to María de los Angeles Ribas.

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Conflict of interest

The authors declare that they have no conflict of interests.

Ethical approval

The study was conducted in accordance with ethical principles expressed in the World Medical Association Declaration of Helsinki. All the procedures involving human participants were in accordance with the ethical standards of the ethics committee at Pedro Kourí Institute of Tropical Medicine (Reference no. CEI-IPK-3712).

Informed consent

Informed consent was obtained from the patients as well as parents and guardians of children provided oral informed consent to the collection of samples for diagnosis.

Additional information

Handling Editor: Bert K. Rima.

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Ribas, M.d.A., Tejero, Y., Valcarcel, M. et al. Mumps epidemiology in Cuba between 2004 and 2015. Arch Virol 163, 3059–3064 (2018). https://doi.org/10.1007/s00705-018-3946-z

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  • DOI: https://doi.org/10.1007/s00705-018-3946-z

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