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BCP/PC mutation prevalence and their association with HBV replication in HIV/HBV co-infected patients

Archives of Virology volume 163, pages 2829–2833 (2018)Cite this article

Abstract

The high prevalence (14.3%) of HIV/HBV co-infections reported in west China makes it necessary to screen concurrent HBV infection in HIV carriers. HBV B genotype was shown to be dominant in 54 cases of HIV/HBV co-infection, accounting for 81.48% of the total. The total drug resistance rate observed was 3.70%. A1762T, G1764A and G1896A mutations were common mutations identified in the BCP/PC region. However, the prevalence of the G1896A mutation was significantly high among the HBeAg negative HIV/HBV co-infected patients, and may be associated with high HBV replication. Mutations in the PC region are related to the loss in synthesis of HBeAg and may accelerate HBV replication in HIV positive patients.

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Acknowledgements

We acknowledge all the colleagues in our laboratory for their assistance with routine testing. We also thank Dr. Shu Feng and Mrs Mengna Zou for reviewing the English and the grammar in the manuscript.

Funding

The present study was supported by: the National Natural Science Foundation of China (#81301400/H1901).

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Affiliations

  1. Division of Clinical microbiology, Department of Laboratory Medicine, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, Republic of China

    Dongdong Li, Qixia Chen & Chuanmin Tao

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  1. Dongdong Li
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  2. Qixia Chen
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  3. Chuanmin Tao
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Corresponding author

Correspondence to Chuanmin Tao.

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The Ethics Committee of West China Hospital of Sichuan University approved this study. All procedures performed in studies involving human participants were in accordance with 1964 Helsinki declaration and its later amendments.

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The authors declare that they have no competing interests

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Handling Editor: Li Wu.

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Li, D., Chen, Q. & Tao, C. BCP/PC mutation prevalence and their association with HBV replication in HIV/HBV co-infected patients. Arch Virol 163, 2829–2833 (2018). https://doi.org/10.1007/s00705-018-3900-0

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  • DOI: https://doi.org/10.1007/s00705-018-3900-0