Serological evidence of H5-subtype influenza A virus infection in indigenous avian and mammalian species in Korea

  • Hye Kwon Kim
  • Hee-Jong Kim
  • Ji Yeong Noh
  • Le Van Phan
  • Ji Hyung Kim
  • Daesub Song
  • Woonsung Na
  • Aram Kang
  • Thi Lan Nguyen
  • Jeong-Hwa Shin
  • Dae Gwin Jeong
  • Sun-Woo Yoon
Original Article

Abstract

In Korea, H5-subtype highly pathogenic avian influenza (HPAI) has caused huge economic losses in poultry farms through outbreaks of H5N1 since 2003, H5N8 since 2013 and H5N6 since 2016. Although it was reported that long-distance migratory birds may play a major role in the global spread of avian influenza viruses (AIVs), transmission from such birds to poultry has not been confirmed. Intermediate hosts in the wild also may be a potential factor in viral transmission. Therefore, a total of 367 serum samples from wild animals were collected near major migratory bird habitats from 2011 to 2016 and tested by AIV-specific blocking ELISA and hemagglutination inhibition (HI) test. Two mammalian and eight avian species were seropositive according to the ELISA test. Among these, two mammalian (Hydropotes inermis and Prionailurus bengalensis) and three avian (Aegypius monachus, Cygnus cygnus, and Bubo bubo) species showed high HI titres (> 1,280) against one or two H5-subtype AIVs. As H. inermis (water deer), P. bengalensis (leopard cat), and B. bubo (Eurasian eagle owl) are indigenous animals in Korea, evidence of H5-subtype AIV in these animals implies that continuous monitoring of indigenous animals should be followed to understand interspecies transmission ecology of H5-subtype influenza viruses.

Notes

Acknowledgements

This project was supported by the Korea Ministry of Environment (20160541125-00). This work was also supported by Grants from the KRIBB Initiative program (Grant no. KGM4691511) and by the BioNano Health-Guard Research Center funded by the Ministry of Science, ICT & Future Planning (MSIP) of Korea as a Global Frontier Project (Grant no. H-GUARD 2013M3A6B2078954). In addition this research was supported by Animal Disease Management Technology Development, Ministry of Agriculture, Food and Rural Affairs (Grant number: 316042-03)

Compliance with ethical standards

Conflict of interest

The authors declare no competing financial interests.

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2017

Authors and Affiliations

  • Hye Kwon Kim
    • 1
  • Hee-Jong Kim
    • 2
  • Ji Yeong Noh
    • 1
    • 3
  • Le Van Phan
    • 4
  • Ji Hyung Kim
    • 1
  • Daesub Song
    • 5
  • Woonsung Na
    • 5
  • Aram Kang
    • 5
  • Thi Lan Nguyen
    • 4
  • Jeong-Hwa Shin
    • 6
  • Dae Gwin Jeong
    • 1
    • 7
  • Sun-Woo Yoon
    • 1
    • 7
  1. 1.Infectious Disease Research CenterKorea Research Institute of Bioscience and BiotechnologyDaejeonRepublic of Korea
  2. 2.Chungnam Wild Animal Rescue CenterYesanRepublic of Korea
  3. 3.College of Veterinary MedicineChungbuk National UniversityCheongjuRepublic of Korea
  4. 4.Department of Microbiology and Infectious Diseases, College of Veterinary MedicineVietnam National University of AgricultureHanoiVietnam
  5. 5.Department of Pharmacy, College of PharmacyKorea UniversitySejongRepublic of Korea
  6. 6.Environmental Health Research DivisionNational Institute of Environmental ResearchIncheonRepublic of Korea
  7. 7.Bio-Analytical Science DivisionUniversity of Science and Technology (UST)DaejeonRepublic of Korea

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