Abstract
Human caliciviruses (HuCVs) have been recognized as a major cause of sporadic viral diarrhea in children, among which norovirus genotype GII.4 is the most prevalent genotype. Stool and saliva samples were collected from 295 children with acute diarrhea and 150 asymptomatic children at a hospital in China. The HuCV detection rate was 10.85% (32/295) among the children with acute diarrhea, and all of these 32 children were either HBGA secretors (12/32) or partial secretors (20/32). HuCV was detected in two (1.33%) of the 150 samples obtained from the asymptomatic children. Of the norovirus-GII.3-positive children, 60% had blood type O, but only 17.29% of the symptomatic patients had blood type O, indicating that type O individuals could be at higher risk of GII.3 infection. However, due to the limited number of individuals in this study, further studies with a larger number of subjects should be conducted to verify this hypothesis.
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This study was funded by National Natural Science Foundation of China (Grant No. 81300296) and Natural Science Foundation of Jiangsu Province (Grant No. BK2012069).
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Author Zhu-lun Zhuang declares that he has no conflict of interest. Author Yu Jin declares that she has no conflict of interest. Author Kun-long Yan declares that he has no conflict of interest. Author Wei-xia Cheng declares that she has no conflict of interest.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study protocol was approved by the hospital ethics committee.
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Informed consent was obtained from all individual participants included in the study. We thank Professor Jiangxi for providing the antibodies for this study.
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Zhuang, Zl., Jin, Y., Yan, Kl. et al. Study of the association between histo-blood group antigens and norovirus infection in Chinese children. Arch Virol 162, 3511–3515 (2017). https://doi.org/10.1007/s00705-017-3494-y
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DOI: https://doi.org/10.1007/s00705-017-3494-y