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Evaluation of the replication and pathogenicity of a variant avian paramyxovirus serotype 6 in mice

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Abstract

Avian paramyxoviruses (APMVs) have been evaluated for their potential use as vaccine vectors, sparking research efforts leading to a better understanding of APMVs’ replication and pathogenicity. However, within APMV serotypes, significant genetic diversity exists, and the infectivity of variant strains in mammals has not been studied. We utilized a mouse model to evaluate the pathogenicity of a variant strain of APMV-6 (APMV-6/red-necked stint/Japan/8KS0813/2008) in comparison with the prototype APMV-6 strain (APMV–6/duck/Hong Kong/18/199/1977). Although the two viruses differ substantially, both genetically and antigenically, we found that the variant and prototype strains could similarly replicate in respiratory tissues of infected mice and induce respiratory disease, sometimes resulting in death of the mice. Both viruses induced a humoral immune response that could be clearly detected by ELISA but which was poorly recognized by the hemagglutination inhibition test.

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Acknowledgements

We thank Sachiko Matsuda in the Obihiro University of Agriculture and Veterinary Medicine for technical support. This work was partially supported by grants from the Program of Founding Research Centers for Emerging and Reemerging Infectious Disease, and by a Grant-in-Aid for Exploratory Research (19659115) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan. This work was also partially supported by the US National Institute of Allergy and Infectious Diseases (NIAID contracts HHSN266200700009C and HHSN266200700007C).

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Authors and Affiliations

  1. Diagnostic Center for Animal Health and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, 2-11 Inada, Obihiro, Hokkaido, 080-8555, Japan

    Vuong Nghia Bui, Dai Quang Trinh, Lary N. B. Abao, Yuki Ozeki, Haruko Ogawa & Kunitoshi Imai

  2. Massachusetts Institute of Technology, Cambridge, MA, 02139, USA

    Jonathan Runstadler

  3. National Institute of Animal Health, Tsukuba, Ibaraki, 305-0856, Japan

    Kikuyasu Nakamura

  4. National Institute of Veterinary Research, 86 Truong Chinh, Dong Da, Hanoi, Vietnam

    Vuong Nghia Bui & Dai Quang Trinh

  5. Department of Agriculture-Agribusiness and Marketing Assistance Service, 1101, Quezon City, Philippines

    Lary N. B. Abao

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  1. Vuong Nghia Bui
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  2. Dai Quang Trinh
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  3. Lary N. B. Abao
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  4. Yuki Ozeki
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  5. Jonathan Runstadler
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  6. Kikuyasu Nakamura
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  7. Haruko Ogawa
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  8. Kunitoshi Imai
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YO was added as an author because of his contribution in performing experiments and data analysis to revise the manuscript.

Corresponding author

Correspondence to Haruko Ogawa.

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Bui, V.N., Trinh, D.Q., Abao, L.N.B. et al. Evaluation of the replication and pathogenicity of a variant avian paramyxovirus serotype 6 in mice. Arch Virol 162, 3035–3043 (2017). https://doi.org/10.1007/s00705-017-3459-1

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  • DOI: https://doi.org/10.1007/s00705-017-3459-1

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