Skip to main content

Detection of mimivirus genome and neutralizing antibodies in humans from Brazil

Abstract

In recent years, giant viruses belonging to the family Mimiviridae have been proposed to be infectious agents in humans. In this work we provide evidence of mimivirus genome and neutralizing antibodies detection in humans.

This is a preview of subscription content, access via your institution.

References

  1. Abrahão JS, Dornas FP, Silva LC, Almeida GM, Boratto PV, Colson P, La Scola B, Kroon EG (2014) Acanthamoeba polyphaga mimivirus and other giant viruses: an open field to outstanding discoveries. Virol J 11:120

    Article  PubMed  PubMed Central  Google Scholar 

  2. Aherfi S, Colson P, Audoly G, Nappez C, Xerri L, Valensi A, Million M, Lepidi H, Costello R, Raoult D (2016) Marseillevirus in lymphoma: a giant in the lymph node. Lancet Infect Dis 16(10):e225–e234

    Article  PubMed  Google Scholar 

  3. Colson P, Aherfi S, Scola La, Raoult D (2016) The role of giant viruses o amoebas in humans. Curr Opin Microbiol 31:199–208

    CAS  Article  PubMed  Google Scholar 

  4. Dornas FP, Rodrigues FP, Boratto PV, Silva LC, Ferreira PC, Bonjardim CA, Trindade GS, Kroon EG, La Scola B, Abrahao JS (2014) Mimivirus circulation among wild and domestic mammals, Amazon Region, Brazil. Emerg Infect Dis 20(3):469–472

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  5. Dornas FP, Silva LC, de Almeida GM, Campos RK, Boratto PV, Franco-Luiz AP, La Scola B, Kroon EG, Abrahao JS (2014) Acanthamoeba polyphaga mimivirus stability in environmental and clinical substrates: implications for virus detection and isolation. PLoS One 9(2):e87811

    Article  PubMed  PubMed Central  Google Scholar 

  6. Hoffmann B, Scheuch M, Höper D, Jungblut R, Holsteg M, Schirrmeier H et al (2012) Novel orthobunyavirus in cattle, Europe, 2011. Emerg Infect Dis 18:469–472. doi:10.3201/eid1803.111905

    Article  PubMed  PubMed Central  Google Scholar 

  7. La Scola B, Audic S, Robert C, Jungang L, de Lamballerie X, Drancourt M, Birtles R, Claverie JM, Raoult D (2003) A giant virus in amoebae. Science 299:2033

    Article  PubMed  Google Scholar 

  8. Saadi H, Pagnier I, Colson P, Cherif JK, Beji M, Boughalmi M, Azza S, Armstrong N, Robert C, Foumous G, La Scola B, Raoult D (2013) First isolation of mimivirus in a patient with pneumonia. Clin Infect Dis 57(4):e127–e134

    Article  PubMed  Google Scholar 

  9. Saadi H, Reteno DG, Colson P, Aherfi S, Minodier P, Pagnier I, La Scola B, Raoult D (2013) Shan virus: a new mimivirus isolated from the stool of a Tunisian patient with pneumonia. Intervirology 56(6):424–429

    Article  PubMed  Google Scholar 

  10. Santos-Silva LK, Arantes TS, Andrade KR, Rodrigues RAL, Boratto PVM, Almeida GMF, Kroon EG, La Scola B, Clemente WT, Abrahão JS (2015) High positivity of mimivirus in inanimate surfaces of a hospital respiratory-isolation facility, Brazil. J Clin Virol 66:62–65

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

We thank our colleagues from Gepvig and the Laboratório de Vírus for their technical support. We also thank Fundação de Amparo à Pesquisa de Minas Gerais (FAPEMIG), CAPES-COFECUB and the Pró-Reitoria de Pesquisa da Universidade Federal de Minas Gerais.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Jônatas S. Abrahão.

Ethics declarations

Conflict of interest

The authors declare no conflicts of interest.

Funding

This study was supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, the Fundação de Amparo à Pesquisa do Estado de Minas Gerais, and the Ministério da Agricultura, Pecuária e Abastecimento. F.P.D. was supported by a fellowship from the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-COFEUB. J.S.A, E.G.K. and G.S.T. are researchers of the Conselho Nacional de Desenvolvimento Científico e Tecnológico.

Electronic supplementary material

Below is the link to the electronic supplementary material.

705_2017_3455_MOESM1_ESM.jpg

Supplemental Figure: A consensus bootstrap phylogenetics neighbor-joining tree based on the nucleotide sequences of the helicase gene from megavirus, and other organisms (1,000 bootstrap replicates implemented by MEGA 6.0). Bootstrap values >40% are shown. Nucleotide sequences were obtained from GenBank. Black dots indicate mimiviruses isolated from rural, asymptomatic, human sera samples. C1 represents serum samples from collection 1, while C2 represents serum samples from collection 2. (JPEG 208 kb)

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Dornas, F.P., Boratto, P.V.M., Costa, G.B. et al. Detection of mimivirus genome and neutralizing antibodies in humans from Brazil. Arch Virol 162, 3205–3207 (2017). https://doi.org/10.1007/s00705-017-3455-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00705-017-3455-5