Skip to main content
SpringerLink
Log in

Salivirus infection in children with diarrhea, Thailand

  • Brief Report
  • Published:
Archives of Virology Aims and scope Submit manuscript

Abstract

A new member of the Picornaviridae family named salivirus, and also known as klassevirus, was identified recently from the feces of children with gastroenteritis. At present, it remains unclear whether salivirus is associated with gastroenteritis in humans and epidemiological data are very limited. To investigate the prevalence of salivirus in Thailand, we performed molecular screening of fecal samples from children hospitalized with acute gastroenteritis in Chiang Mai, Thailand during 2015-2016 through the application of RT-nested PCR. Salivirus was detected in 1 out of 229 (0.44%) fecal samples tested and it belonged to genotype A1, based on nucleotide sequences of the 5’UTR, VP1, and 3D regions. This is the first report of salivirus infection in young children with acute diarrhea in Thailand.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Aldabbagh S, Eckerle I, Muller A, Delwart EL, Eis-Hubinger AM (2015) Salivirus type 1 and type 2 in patients with acute gastroenteritis, Germany. J Clin Virol 72:16–19

    Article  PubMed  Google Scholar 

  2. Ayouni S, Estienney M, Hammami S, Neji Guediche M, Pothier P, Aouni M, Belliot G, de Rougemont A (2016) Cosavirus, Salivirus and Bufavirus in Diarrheal Tunisian Infants. PLoS One 11:e0162255

    Article  PubMed  PubMed Central  Google Scholar 

  3. Boros A, Raab M, Karoly E, Karai A, Katai A, Bolba N, Pankovics P, Reuter G (2016) A cluster of salivirus A1 (Picornaviridae) infections in newborn babies with acute gastroenteritis in a neonatal hospital unit in Hungary. Arch Virol 161:1671–1677

    Article  CAS  PubMed  Google Scholar 

  4. Han TH, Kim CH, Chung JY, Park SH, Hwang ES (2010) Klassevirus infection in children, South Korea. Emerg Infect Dis 16:1623–1625

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Haramoto E, Kitajima M, Otagiri M (2013) Development of a reverse transcription-quantitative PCR assay for detection of salivirus/klassevirus. Appl Environ Microbiol 79:3529–3532

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Holtz LR, Finkbeiner SR, Zhao G, Kirkwood CD, Girones R, Pipas JM, Wang D (2009) Klassevirus 1, a previously undescribed member of the family Picornaviridae, is globally widespread. Virol J 6:86

    Article  PubMed  PubMed Central  Google Scholar 

  7. Itta KC, Patil T, Kalal S, Ghargi KV, Roy S (2016) Salivirus in children with diarrhoea, western India. Int J Infect Dis 52:14–15

    Article  PubMed  Google Scholar 

  8. Khamrin P, Okame M, Thongprachum A, Nantachit N, Nishimura S, Okitsu S, Maneekarn N, Ushijima H (2011) A single-tube multiplex PCR for rapid detection in feces of 10 viruses causing diarrhea. J Virol Methods 173:390–393

    Article  CAS  PubMed  Google Scholar 

  9. Lasure N, Gopalkrishna V (2016) Clinico-epidemiology and genetic diversity of Salivirus in acute gastroenteritis cases from Pune, Western India: 2007-2011. Infect Gene Evol J Mol Epidemiol Evol Gene Infect Dis 44:425–430

    CAS  Google Scholar 

  10. Li L, Victoria J, Kapoor A, Blinkova O, Wang C, Babrzadeh F, Mason CJ, Pandey P, Triki H, Bahri O, Oderinde BS, Baba MM, Bukbuk DN, Besser JM, Bartkus JM, Delwart EL (2009) A novel picornavirus associated with gastroenteritis. J Virol 83:12002–12006

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Ng TF, Marine R, Wang C, Simmonds P, Kapusinszky B, Bodhidatta L, Oderinde BS, Wommack KE, Delwart E (2012) High variety of known and new RNA and DNA viruses of diverse origins in untreated sewage. J Virol 86:12161–12175

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Nielsen AC, Gyhrs ML, Nielsen LP, Pedersen C, Bottiger B (2013) Gastroenteritis and the novel picornaviruses aichi virus, cosavirus, saffold virus, and salivirus in young children. J Clin Virol 57:239–242

    Article  PubMed  Google Scholar 

  13. Reuter G, Pankovics P, Boros A (2017) Saliviruses—the first knowledge about a newly discovered human picornavirus. Rev Med Virol 27(1):e1904. doi:10.1002/rmv.1904

    Article  Google Scholar 

  14. Santos N, Mendes GS, Silva RC, Pena GA, Rojas M, Amorim AR, Lima DP (2015) Salivirus and aichivirus A infections in children with gastroenteritis in Brazil. Clin Microbiol Infect 21:799.e791–799.e793

    Article  Google Scholar 

  15. Shan T, Wang C, Cui L, Yu Y, Delwart E, Zhao W, Zhu C, Lan D, Dai X, Hua X (2010) Picornavirus salivirus/klassevirus in children with diarrhea, China. Emerg Infect Dis 16:1303–1305

    Article  PubMed  PubMed Central  Google Scholar 

  16. Yip CC, Lo KL, Que TL, Lee RA, Chan KH, Yuen KY, Woo PC, Lau SK (2014) Epidemiology of human parechovirus, Aichi virus and salivirus in fecal samples from hospitalized children with gastroenteritis in Hong Kong. Virol J 11:182

    Article  PubMed  PubMed Central  Google Scholar 

  17. Yu JM, Ao YY, Liu N, Li LL, Duan ZJ (2015) Salivirus in children and its association with childhood acute gastroenteritis: a paired case-control study. PLoS One 10:e0130977

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

This work was supported by the Faculty of Medicine and the Center of Excellence (Emerging and Re-emerging Diarrheal Viruses Research Center, grant number ST6592(11)/R419), Chiang Mai University, Chiang Mai, Thailand.

Author information

Authors and Affiliations

  1. Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand

    Kattareeya Kumthip, Pattara Khamrin, Arpaporn Yodmeeklin & Niwat Maneekarn

Authors
  1. Kattareeya Kumthip
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pattara Khamrin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Arpaporn Yodmeeklin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Niwat Maneekarn
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Niwat Maneekarn.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This study was approved by the Ethical Committee for Human Rights Related to Human Experimentation, Faculty of Medicine, Chiang Mai University (MIC-2557-02710).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kumthip, K., Khamrin, P., Yodmeeklin, A. et al. Salivirus infection in children with diarrhea, Thailand. Arch Virol 162, 2839–2841 (2017). https://doi.org/10.1007/s00705-017-3435-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00705-017-3435-9

Keywords

Search

Navigation