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Delayed progression of rabies transmitted by a vampire bat

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Abstract

Here, we compared the growth kinetics, cell-to-cell spread, and virus internalization kinetics in N2a cells of RABV variants isolated from vampire bats (V-3), domestic dogs (V-2) and marmosets (V-M) as well as the clinical symptoms and mortality caused by these variants. The replication rate of V-3 was significantly higher than those of V-2 and V-M. However, the uptake and spread of these RABV variants into N2a cells were inversely proportional. Nevertheless, V-3 had longer incubation and evolution periods. Our results provide evidence that the clinical manifestations of infection with bat RABV variant occur at a later time when compared to what was observed with canine and marmoset rabies virus variants.

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Acknowledgments

We would like to thank Keila Iamamoto Nogi and Willian de Oliveira Fahl for testing the RABV virus samples. We would like to thank Leo Iwai and Liron Kufert for refining the use of English in the manuscript.

This work was supported by Instituto Pasteur/Brazil.

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Authors and Affiliations

  1. Laboratório de Diagnóstico da Raiva, Instituto Pasteur of São Paulo, São Paulo, SP, Brazil

    Iana Suly Santos Katz, Natalia Langenfeld Fuoco, Luciana Botelho Chaves, Adriana Candido Rodrigues, Karin Corrêa Scheffer & Karen Miyuki Asano

  2. Laboratório de Imunogenética, Instituto Butantan of São Paulo, São Paulo, SP, Brazil

    Orlando Garcia Ribeiro

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  1. Iana Suly Santos Katz
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  2. Natalia Langenfeld Fuoco
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  3. Luciana Botelho Chaves
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Correspondence to Iana Suly Santos Katz.

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Katz, I.S.S., Fuoco, N.L., Chaves, L.B. et al. Delayed progression of rabies transmitted by a vampire bat. Arch Virol 161, 2561–2566 (2016). https://doi.org/10.1007/s00705-016-2927-3

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  • DOI: https://doi.org/10.1007/s00705-016-2927-3

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