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Distribution of hepatitis C virus genotypes in volunteer blood donors from Chengdu, China

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Abstract

Hepatitis C virus (HCV) is a significant pathogen of global concern. The virus is usually spread through blood contact, such as transfusion, hemodialysis and injection of illegal drugs. HCV genotypes have a geographic distribution in different areas. In this paper, we focus on the distribution of HCV genotypes from volunteer blood donors in Chengdu. The prevalence of genotypes was analyzed using phylogenetic analysis. Phylogenetic trees were constructed based on the HCV core and NS5B regions from 313 sequences. HCV sequences were classified into six subtypes, and HCV genotypes were determined with the following results: 1b in 283, 2a in 14, 3b in seven, 3a in three, 6a in five and 6u in one. Subtype 1b was the most common and accounted for approximately 90.41 % (283/313), and a virus of subtype 6u was isolated for the first time from the Chengdu area. Genotypes 4 and 5 were not detected.

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Authors and Affiliations

  1. Blood Research Laboratory, Chengdu Blood Center, Chengdu, 610041, Sichuan, China

    Tianxiang Gong, Ying Hong & Xuemei Fu

  2. Blood Screening Laboratory, Chengdu Blood Center, Chengdu, 610041, Sichuan, China

    Xin Zhao & Shuping Li

  3. College of Pharmacy, Purdue University, West Lafayette, IN, 47907, USA

    Yijia Luo

Authors
  1. Tianxiang Gong
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  2. Xin Zhao
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  3. Yijia Luo
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  4. Ying Hong
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  5. Shuping Li
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  6. Xuemei Fu
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Correspondence to Tianxiang Gong.

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The authors have no any conflict of interest or financial involvement regarding this manuscript.

Each author contributed substantially to the work, is in agreement with the content of the manuscript, and approved the submission.

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Gong, T., Zhao, X., Luo, Y. et al. Distribution of hepatitis C virus genotypes in volunteer blood donors from Chengdu, China. Arch Virol 161, 1873–1882 (2016). https://doi.org/10.1007/s00705-016-2865-0

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  • DOI: https://doi.org/10.1007/s00705-016-2865-0

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