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An epidemic of coxsackievirus B3 infection in infants and children in Jiangsu Province, China: a prospective cohort study

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Abstract

To investigate the epidemiological data on coxsackievirus B3 (CVB3) infection and its incidence in infants and children, a prospective cohort study was carried out from 2012 to 2014 in Jiangsu Province, China. According to the results of seropositive rates and NTAb titers of CVB3, an epidemic of CVB3 infection was found, and a dynamic change in CVB3 neutralizing antibody was also observed. One case was recorded with CVB3-associated hand, foot and mouth disease (HFMD), and the isolates belonged to the CVB3 D2 subtype. Our data help us to better understand the epidemic characteristics of CVB3 infection in infants and children.

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Fig. 1

Abbreviations

HFMD:

Hand, foot and mouth disease

CVB3:

Coxsackievirus B3

NTAb:

Neutralizing antibodies

CPE:

Cytopathic effect

AFP:

Acute flaccid paralysis

GMT:

Geometric mean titer

EV71:

Enterovirus 71

CA16:

Coxsackievirus A16

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Acknowledgments

We thank the Jiangsu Provincial Center for Disease Control and Prevention for help in collecting samples. We thank the Major Special Projects Funding Program (No. 2012ZX09304010) and National High Technology Research and Development Program (“863” program, No. 2012AA02A402) from the Ministry of Science and Technology of the People’s Republic of China for their support.

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Authors and Affiliations

  1. National Institutes for Food and Drug Control, No. 2, Tiantan Xili, Beijing, 100050, People’s Republic of China

    Fan Gao, Lian-lian Bian, Qun-ying Mao, Pan Chen, Xin Yao & Zheng-lun Liang

  2. Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, People’s Republic of China

    Jing-xin Li & Feng-cai Zhu

Authors
  1. Fan Gao
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  2. Lian-lian Bian
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  3. Qun-ying Mao
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  4. Pan Chen
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  5. Xin Yao
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  6. Jing-xin Li
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  7. Feng-cai Zhu
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  8. Zheng-lun Liang
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Corresponding author

Correspondence to Zheng-lun Liang.

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Ethical standard

The study was approved by the institutional review board of Jiangsu Provincial Center of Disease Control and Prevention and was done in accordance with the Declaration of Helsinki, Good Clinical Practice, and Chinese regulatory requirements.

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Gao, F., Bian, Ll., Mao, Qy. et al. An epidemic of coxsackievirus B3 infection in infants and children in Jiangsu Province, China: a prospective cohort study. Arch Virol 161, 1945–1947 (2016). https://doi.org/10.1007/s00705-016-2842-7

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  • DOI: https://doi.org/10.1007/s00705-016-2842-7

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