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The relationship between hepatitis B virus (HBV) load and levels of transforming growth factor beta 1 (TGF-β1) and soluble Fas (sFas) in human immunodeficiency virus patients with occult HBV infection

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Abstract

The aim of this study was to evaluate the correlation between hepatitis B virus (HBV) load and serum levels of transforming growth factor beta 1 (TGF-β1) and soluble Fas (sFas) cytokines in human immunodeficiency virus (HIV) patients who have never been treated with antiretroviral therapy. HBV and hepatitis C virus (HCV) serological markers, sFas and TGF-β1 levels, and HBV load were evaluated in 116 patients. While there was no correlation between TGF-β1 levels and HBV load, a positive correlation between sFas levels and HBV load was observed in patients with occult HBV infection.

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Conflict of interest

The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Virology Division, Keizo Asami Immunopathology Laboratory (LIKA), Federal University of Pernambuco (UFPE), Recife, Brazil

    Jéfferson Luis de Almeida Silva, Dayse Maria Vasconcelos De Deus & Maria Rosângela Cunha Duarte Coêlho

  2. Viral Hepatitis Laboratory, Adolfo Lutz Institute, São Paulo, Brazil

    Regina Célia Moreira

  3. Department of Immunology, Centro de Pesquisas Aggeu Magalhães (CPqAM), Recife, Brazil

    Clarice Neuenschwander Lins de Morais

  4. Department of Physiology and Pharmacology, Center of Health Sciences, UFPE, Recife, Brazil

    Maria Rosângela Cunha Duarte Coêlho

  5. Post Graduate Program in Tropical Medicine, Center of Health Sciences, UFPE, Recife, Brazil

    Maria Rosângela Cunha Duarte Coêlho

  6. Rua Manuel Lubambo 118, Afogados, Recife, PE, 50850-040, Brazil

    Maria Rosângela Cunha Duarte Coêlho

Authors
  1. Jéfferson Luis de Almeida Silva
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  2. Dayse Maria Vasconcelos De Deus
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  3. Regina Célia Moreira
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  4. Clarice Neuenschwander Lins de Morais
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  5. Maria Rosângela Cunha Duarte Coêlho
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Corresponding author

Correspondence to Maria Rosângela Cunha Duarte Coêlho.

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de Almeida Silva, J.L., De Deus, D.M.V., Moreira, R.C. et al. The relationship between hepatitis B virus (HBV) load and levels of transforming growth factor beta 1 (TGF-β1) and soluble Fas (sFas) in human immunodeficiency virus patients with occult HBV infection. Arch Virol 160, 1801–1804 (2015). https://doi.org/10.1007/s00705-015-2445-8

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  • DOI: https://doi.org/10.1007/s00705-015-2445-8

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