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Archives of Virology

, Volume 160, Issue 2, pp 375–387 | Cite as

Insights into the functional characteristics of geminivirus rolling-circle replication initiator protein and its interaction with host factors affecting viral DNA replication

  • Irum Rizvi
  • Nirupam Roy Choudhury
  • Narendra Tuteja
Brief Review

Abstract

Geminiviruses are DNA viruses that infect several economically important crops, resulting in a reduction in their overall yield. These plant viruses have circular, single-stranded DNA genomes that replicate mainly by a rolling-circle mechanism. Geminivirus infection results in crosstalk between viral and cellular factors to complete the viral life cycle or counteract the infection as part of defense mechanisms of host plants. The geminiviral replication initiator protein Rep is the only essential viral factor required for replication. It is multifunctional and is known to interact with a number of host factors to modulate the cellular environment or to function as a part of the replication machinery. This review provides a holistic view of the research related to the viral Rep protein and various host factors involved in geminiviral DNA replication. Studies on the promiscuous nature of geminiviral satellite DNAs are also reviewed.

Keywords

Proliferate Cell Nuclear Antigen Tomato Yellow Leaf Curl Virus Mungbean Yellow Mosaic India Virus African Cassava Mosaic Virus Replication Initiator Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

IR is thankful to Department of Biotechnology (DBT), India, for funding her scholarship.

Conflict of interest

The authors declare that they have no competing interests.

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© Springer-Verlag Wien 2014

Authors and Affiliations

  1. 1.Plant Molecular Biology GroupInternational Centre for Genetic Engineering and BiotechnologyNew DelhiIndia

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