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Greater virulence of highly pathogenic H5N1 influenza virus in cats than in dogs

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Abstract

Highly pathogenic H5N1 influenza virus continues to infect animals and humans. We compared the infectivity and pathogenesis of H5N1 virus in domestic cats and dogs to find out which animal is more susceptible to H5N1 influenza virus. When cats and dogs were infected with the H5N1 virus, cats suffered from severe outcomes including death, whereas dogs did not show any mortality. Viruses were shed in the nose and rectum of cats and in the nose of dogs. Viruses were detected in brain, lung, kidney, intestine, liver, and serum in the infected cats, but only in the lung in the infected dogs. Genes encoding inflammatory cytokines and chemokines, Toll-like receptors, and apoptotic factors were more highly expressed in the lungs of cats than in those of dogs. Our results suggest that the intensive monitoring of dogs is necessary to prevent human infection by H5N1 influenza virus, since infected dogs may not show clear clinical signs, in contrast to infected cats.

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Acknowledgments

This work was funded by the Basic Science Research Program through the National Research Foundation of Korea (NRF) from the Ministry of Education, Science and Technology (2012R1A2A2A 01002533). A scientific editor from Editage edited this manuscript.

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Authors and Affiliations

  1. Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, 220 Gung Dong, Yuseong Gu, Daejeon, 305-764, Republic of Korea

    Heui Man Kim, Eun Hye Park, Jung Yum & Sang Heui Seo

  2. Institute of Influenza Virus, College of Veterinary Medicine, Chungnam National University, Daejeon, 305-764, Republic of Korea

    Heui Man Kim, Eun Hye Park, Jung Yum & Sang Heui Seo

  3. Laboratory of Public Health, College of Veterinary Medicine, Chungnam National University, Daejeon, 305-764, Republic of Korea

    Hyun Soo Kim

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  1. Heui Man Kim
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  2. Eun Hye Park
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Correspondence to Sang Heui Seo.

Additional information

H. M. Kim, E. H. Park and J. Yum equally contributed to this work.

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Kim, H.M., Park, E.H., Yum, J. et al. Greater virulence of highly pathogenic H5N1 influenza virus in cats than in dogs. Arch Virol 160, 305–313 (2015). https://doi.org/10.1007/s00705-014-2284-z

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  • DOI: https://doi.org/10.1007/s00705-014-2284-z

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