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Identification and full-length molecular characterization of rare hepatitis C virus genotype 5a from India

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Abstract

This report presents a molecular characterization of the complete genome of a rare hepatitis C virus (HCV) genotype (GT5a) from India. Sequence homology of full genome revealed that the strain belonged to HCV GT5a. To trace the origin of this virus and to understand its evolutionary pattern, a phylogenetic reconstruction was carried out on full HCV genome sequences using Bayesian coalescent methods. The phylogenetic tree reconstruction revealed genotypic divergence, with formation of distinct clades. This analysis revealed that HCV genotype 5 might have originated from HCV genotype 3, as they have a recent common ancestor.

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Acknowledgments

This study was funded by the Department of Biotechnology vide Grant No. BT/BIPP/03/07/0322/10, India.

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Authors and Affiliations

  1. Department of Research, Institute of Liver and Biliary Sciences (ILBS), Vasant Kunj, New Delhi, 110070, India

    Manish Chandra Choudhary, Vidhya Natarajan & Shvetank Sharma

  2. Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India

    Manish Chandra Choudhary & Syed N. Kazim

  3. Department of Virology, Institute of Liver and Biliary Sciences (ILBS), Vasant Kunj, New Delhi, 110070, India

    Ekta Gupta & Priyanka Pandey

  4. Department of Hepatology, Institute of Liver and Biliary Sciences (ILBS), Vasant Kunj, New Delhi, 110070, India

    Chitranshu Vashishtha, Manoj Kumar Sharma & Shiv K. Sarin

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  1. Manish Chandra Choudhary
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  2. Ekta Gupta
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  3. Priyanka Pandey
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  4. Vidhya Natarajan
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  9. Shiv K. Sarin
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Correspondence to Shiv K. Sarin.

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Choudhary, M.C., Gupta, E., Pandey, P. et al. Identification and full-length molecular characterization of rare hepatitis C virus genotype 5a from India. Arch Virol 160, 329–333 (2015). https://doi.org/10.1007/s00705-014-2220-2

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  • DOI: https://doi.org/10.1007/s00705-014-2220-2

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