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Low infectivity of a novel avian-origin H7N9 influenza virus in pigs

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Abstract

We studied the pathogenesis and transmissibility of a novel avian-origin H7N9 influenza virus in pigs. When pigs were infected with H7N9 influenza virus, they did not show any clear clinical signs (such as sneezing, fever and loss of body weight), and they shed viruses through their noses for 2 days after infection. No transmission occurred between infected and naïve pigs. Pigs suffered from mild pneumonia, which was accompanied by the induction of inflammatory cytokines and chemokines such as IL-8 and CCL1. Taken together, our results suggest that pigs may not play an active role in transmitting H7N9 influenza virus to mammals.

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Acknowledgments

This study was supported in part by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2012R1A2A2A01002533). A scientific editor from Editage edited this manuscript.

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Authors and Affiliations

  1. Laboratory of Influenza Research, College of Veterinary Medicine, Institute for Influenza Virus, Chungnam National University, 220 Gung Dong, Yuseong Gu, Daejeon, 305-764, Republic of Korea

    Jung Yum, Eun Hye Park, Keun Bon Ku, Ji An Kim, Seung Kyoo Oh & Sang Heui Seo

  2. Institute of Influenza Virus, College of Veterinary Medicine, Chungnam National University, Daejeon, 305-764, Republic of Korea

    Jung Yum, Eun Hye Park, Keun Bon Ku, Ji An Kim, Seung Kyoo Oh & Sang Heui Seo

  3. Laboratory of Public Health, College of Veterinary Medicine, Chungnam National University, Daejeon, 305-764, Republic of Korea

    Hyun Soo Kim

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  1. Jung Yum
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  2. Eun Hye Park
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  3. Keun Bon Ku
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  4. Ji An Kim
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  5. Seung Kyoo Oh
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Correspondence to Sang Heui Seo.

Additional information

J. Yum and E. H. Park contributed to this work.

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Yum, J., Park, E.H., Ku, K.B. et al. Low infectivity of a novel avian-origin H7N9 influenza virus in pigs. Arch Virol 159, 2745–2749 (2014). https://doi.org/10.1007/s00705-014-2143-y

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  • DOI: https://doi.org/10.1007/s00705-014-2143-y

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