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Analysis of the full-length VP2 protein of canine parvoviruses circulating in Hungary

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Abstract

In recent years, the number of cases of disease caused by canine parvovirus 2 (CPV-2) in vaccinated dogs has increased. The aim of the present study was to identify CPV-2 strains present in Hungary. Forty-two out of 50 faecal specimens examined were positive, and 25 VP2 sequences were determined and analysed. Based on the current classification, the Hungarian viruses belong to New CPV-2a type, except two viruses that are recombinants of vaccine viruses and CPV-2a strains. The Tyr324Ile alteration was detected for the first time in Europe, and a “Hungarian-specific” substitution (Ala516Thr) was also identified in this study. The immunologically important parts of the currently spreading canine parvoviruses were examined and found to differ greatly from the vaccine strains that are widely used in Hungary.

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Acknowledgments

This paper was supported by the TÁMOP 4.2.2.B-10/1-2010-0011 Grant of the Szent István University, Faculty of Veterinary Science.

Conflict of interest

None of the authors of this paper has a financial or personal relationship with other people or organisations that could inappropriately influence or bias the content of the paper.

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Correspondence to Attila Cságola.

Additional information

Nucleotide sequence data reported here are available in the GenBank database under the following Accession Numbers: KF539789-KF539805.

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Cságola, A., Varga, S., Lőrincz, M. et al. Analysis of the full-length VP2 protein of canine parvoviruses circulating in Hungary. Arch Virol 159, 2441–2444 (2014). https://doi.org/10.1007/s00705-014-2068-5

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  • DOI: https://doi.org/10.1007/s00705-014-2068-5

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