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Effects of equid herpesvirus 1 (EHV-1) AR8 and HH1 strains on BALB-c mice

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Abstract

Here, we used a murine model to describe and compare the pathogenic potential of the Argentinean equid herpesvirus 1 (EHV-1) AR8 strain with the Japanese HH1 reference strain. In AR8-inoculated animals, clinical signs began earlier, but the viremic phase was shorter. Virus isolation and DNA detection in the lungs, liver and spleen were positive for both strains at different times postinfection (pi). Infection foci produced by both strains were immunohistochemically detected in lungs from day 1 to day 4 pi. We conclude that whichever EHV-1 strain is selected to experimentally reproduce the disease, it needs appropriate standardization in order to provide valid conclusions.

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Acknowledgments

This study was supported by PICT 2011-1123 (FONCYT) and grants from CIC PBA, the Department for Science and Technology of the National University of La Plata (SeCyT), and the National Academy of Agronomy and Veterinary (ANAV), Argentina. We thank Rosa Villegas, Guadalupe Guidi and Claudio A. Leguizamón for their technical support.

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Authors and Affiliations

  1. Department of Histology and Embryology. School of Veterinary Sciences, National University of La Plata, 60 and 118 streets, postal code 1900, La Plata, Buenos Aires, Argentina

    Carolina Zanuzzi & Claudio Barbeito

  2. Department of Virology, School of Veterinary Sciences, National University of La Plata, La Plata, Buenos Aires, Argentina

    Mariela Scrochi, Nadia Fuentealba & Cecilia Galosi

  3. Department of General Pathology, School of Veterinary Sciences, National University of La Plata, La Plata, Buenos Aires, Argentina

    Carolina Zanuzzi, Fabián Nishida, Enrique Portiansky, Eduardo Gimeno & Claudio Barbeito

  4. Department of Biological Sciences, LISIN Laboratory, School of Exact Sciences, National University of La Plata, 115 and 47 streets, La Plata, Buenos Aires, Argentina

    Cecilia Muglia

  5. National Scientific and Technical Research Council (CONICET-CCT La Plata), La Plata, Argentina

    Carolina Zanuzzi, Mariela Scrochi, Nadia Fuentealba, Fabián Nishida, Enrique Portiansky, Cecilia Muglia, Eduardo Gimeno & Claudio Barbeito

  6. Scientific Research Commission of Buenos Aires Province (CIC-PBA), La Plata, Argentina

    Cecilia Galosi

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  1. Carolina Zanuzzi
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  2. Mariela Scrochi
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  3. Nadia Fuentealba
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  7. Eduardo Gimeno
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  8. Claudio Barbeito
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  9. Cecilia Galosi
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Correspondence to Carolina Zanuzzi.

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Zanuzzi, C., Scrochi, M., Fuentealba, N. et al. Effects of equid herpesvirus 1 (EHV-1) AR8 and HH1 strains on BALB-c mice. Arch Virol 159, 141–145 (2014). https://doi.org/10.1007/s00705-013-1782-8

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  • DOI: https://doi.org/10.1007/s00705-013-1782-8

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