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Dynamics of cellular immune responses in the acute phase of dengue virus infection

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Abstract

In this study, we examined the dynamics of cellular immune responses in the acute phase of dengue virus (DENV) infection in a marmoset model. Here, we found that DENV infection in marmosets greatly induced responses of CD4/CD8 central memory T and NKT cells. Interestingly, the strength of the immune response was greater in animals infected with a dengue fever strain than in those infected with a dengue hemorrhagic fever strain of DENV. In contrast, when animals were re-challenged with the same DENV strain used for primary infection, the neutralizing antibody induced appeared to play a critical role in sterilizing inhibition against viral replication, resulting in strong but delayed responses of CD4/CD8 central memory T and NKT cells. The results in this study may help to better understand the dynamics of cellular and humoral immune responses in the control of DENV infection.

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Acknowledgments

We would like to give special thanks to members of The Corporation for Production and Research of Laboratory Primates for technical assistance. We also appreciate Ms. Tomoko Ikoma and Mizuho Fujita for technical assistance. This work was supported by grants from the Ministry of Health, Labor and Welfare of Japan, and by the Environment Research and Technology Development Fund (D-1007) from the Ministry of the Environment of Japan.

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Authors and Affiliations

  1. Tsukuba Primate Research Center, National Institute of Biomedical Innovation, 1-1 Hachimandai, Tsukuba, Ibaraki, 305-0843, Japan

    Tomoyuki Yoshida, Yuki Iwasaki, Terue Kurosawa, Masataka Hamano, Yasuhiro Yasutomi & Hirofumi Akari

  2. Center for Human Evolution Modeling Research, Primate Research Institute, Kyoto University, Inuyama, Aichi, 484-8506, Japan

    Tomoyuki Yoshida, Akatsuki Saito, Atsunori Higashino & Hirofumi Akari

  3. Department of Virology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan

    Tsutomu Omatsu, Tomohiko Takasaki & Ichiro Kurane

  4. Corporation for Production and Research of Laboratory Primates, 1-1 Hachimandai, Tsukuba, Ibaraki, 305-0843, Japan

    Yuko Katakai

  5. Research Center for Animal Life Science, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan

    Shinichiro Nakamura

Authors
  1. Tomoyuki Yoshida
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  2. Tsutomu Omatsu
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  8. Atsunori Higashino
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  11. Yasuhiro Yasutomi
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  12. Ichiro Kurane
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  13. Hirofumi Akari
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Corresponding authors

Correspondence to Tomoyuki Yoshida or Hirofumi Akari.

Additional information

T. Yoshida and T. Omatsu contributed equally to this study.

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Yoshida, T., Omatsu, T., Saito, A. et al. Dynamics of cellular immune responses in the acute phase of dengue virus infection. Arch Virol 158, 1209–1220 (2013). https://doi.org/10.1007/s00705-013-1618-6

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  • DOI: https://doi.org/10.1007/s00705-013-1618-6

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