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Unique characteristics of bat rabies viruses in big brown bats (Eptesicus fuscus)

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Abstract

Rabies virus infection has been documented in several North American bat species, including Eptesicus fuscus. The virus-host relationship between bats and rabies virus (RV) is not well understood. The incidence of non-lethal RV exposure, based on the presence of viral neutralizing antibodies, demonstrates that exposure to RV does not always lead to clinical infection in bats. It is unknown how the route of exposure, rabies virus variant, or health of the bat affects the outcome following exposure. This paper describes the pathogenesis of two big brown bat RV variants in homologous host species. Our study demonstrates that RV variants obtained from the same species of bat from similar geographical areas may result in a diverse clinical progression of disease.

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Authors and Affiliations

  1. Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, 80524, USA

    April D. Davis

  2. Rabies Laboratory, New York State Department of Health, Wadsworth Center, 5668 State Farm Road, Slingerlands, NY, 12159, USA

    April D. Davis

  3. Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, 80524, USA

    Paul A. Gordy & Richard A. Bowen

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  1. April D. Davis
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  2. Paul A. Gordy
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  3. Richard A. Bowen
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Correspondence to April D. Davis.

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Davis, A.D., Gordy, P.A. & Bowen, R.A. Unique characteristics of bat rabies viruses in big brown bats (Eptesicus fuscus). Arch Virol 158, 809–820 (2013). https://doi.org/10.1007/s00705-012-1551-0

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