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SEN virus detection in thalassemic patients infected with hepatitis C virus

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Abstract

HCV infection is known to be associated with clinical complications in thalassemic patients. D and H genotypes of SEN virus (SENV) are associated with blood-product transfusion and possibly non-A-to-E hepatitis. In this study, SENV viremia and its effect on liver ALT level in thalassemic patients, thalassemic patients infected with HCV, and HCV-infected patients were examined. Semi-nested PCR was conducted for detection of genotype H and D DNA, and the level of alanine aminotransferase (ALT) was measured. There was no significant difference in the mean ALT level in the studied groups and between SENV-positive and SENV-negative individuals. The results also showed that SENV infection does not affect the ALT level in these patients.

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References

  1. Primi DG, Fiordalisi GL, Mantero S et al (2000) Identification of SENV genotypes. International patent number WO 00/28039 (International application published under the patent cooperation treaty). Internet address: http://ep.espacenet.com/

  2. Tanaka Y, Primi D, Wang RYH et al (2001) Genomic and molecular evolutionary analysis of a newly identified infectious agent (SEN virus) and its relationship to the TT virus family. J Infect Dis 183:359–367

    Article  PubMed  CAS  Google Scholar 

  3. Umemura T, Yeo AE, Sottini A et al (2001) SEN virus infection and its relationship to transfusion-associated hepatitis. Hepatology 33:1303–1311

    Article  PubMed  CAS  Google Scholar 

  4. Hosseini-Moghadam SM, Mousavi SH, Alavian SM (2009) Is SEN virus a major concern in hemodialysis and liver transplantation? Hepat Mon 9(1):50–59

    Google Scholar 

  5. Mirmomen S, Alavian SM, Hajarizadeh B et al (2006) Epidemiology of hepatitis B, hepatitis C, and human immunodeficiency virus infections in patients with beta-thalassemia in Iran: A multicenter study. Arch Iran Med 9(4):319–323

    PubMed  Google Scholar 

  6. Ventoa S, Cainelli F, Cesario F (2006) Infections and thalassaemia. Lancet Infect Dis 6:226–233

    Article  Google Scholar 

  7. Costello M, Yungbluth M (2001) Viral infections. In: Henry JB (ed) Clinical diagnosis and management by laboratory methods, 20th edn. WB Saunders, Philadelphia, pp 1064–1066

    Google Scholar 

  8. Abolghasemi H, Amid A, Zeinali S et al (2007) Thalassemia in Iran epidemiology, prevention, and management. J Pediat Hematol Onc 29:233–238

    Article  Google Scholar 

  9. Alavian SM, Tabatabaei SV, Lankarani KB (2010) Epidemiology of HCV infection among thalassemia patients in Eastern Mediterranean countries: a quantitative review of literature. Iran Red Crescent Me 12(4):365–376

    Google Scholar 

  10. Mu SJ, Du J, Zhan LS, Wang HP, Chen R, Wang QL et al (2004) Prevalence of a newly identified SEN virus in China. World J Gastroenterol 10:2402–2405

    PubMed  CAS  Google Scholar 

  11. Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S (2011) MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods (MEGA) software version 5. Mol Biol Evol 28(10):2731–2739

    Article  PubMed  CAS  Google Scholar 

  12. Saitou N, Nei M (1987) The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol 4:406–425

    PubMed  CAS  Google Scholar 

  13. Tamura K, Nei M, Kumar S (2004) Prospects for inferring very large phylogenies by using the neighbor-joining method. PNAS 101:11030–11035

    Article  PubMed  CAS  Google Scholar 

  14. Lin JG, Goto T, Nakane K et al (2003) Clinical significance of SEN-virus on interferon response in chronic hepatitis C patients. J Gastroenterol Hepatol 18:1144–1149

    Article  PubMed  CAS  Google Scholar 

  15. Kao JH, Chen W, Chen PJ, Lai MY, Chen DS (2002) Prevalence and implication of a newly identified infectious agent (SEN virus) in Taiwan. J Infect Dis 185:389–392

    Article  PubMed  Google Scholar 

  16. Alavian SM, Fallahian F (2008) Comparison of seroepidemiology and transmission modes of viral Hepatitis C in Iran and Pakistan. Hepat Mon 8(1):51–59

    Google Scholar 

  17. Karimi-Rastehkenari A, Bouzari M (2010) High frequency of SEN virus infection in thalassemic patients and healthy blood donors in Iran. Virol J 7:1

    Article  PubMed  Google Scholar 

  18. Sharifi Z, Mahmoodian-Shooshtari M, Talebian A (2008) The prevalence of SEN virus infection in blood donors in Iran. Arch Iran Med 11:423–426

    PubMed  CAS  Google Scholar 

  19. Sagir A, Adams O, Kirschberg O, Erhardt A, Heintges T, Häussinger D (2004) SEN virus does not affect treatment response in hepatitis C virus coinfected patients but SEN virus response depends on SEN virus DNA concentration. World J Gastroenterol 10(13):1893–1897

    PubMed  Google Scholar 

  20. Umemura T, Alter HJ, Tanaka E et al (2001) Association between SEN virus infection and hepatitis C in Japan. J Infect Dis 145:1246–1251

    Article  Google Scholar 

  21. Umemura T, Alter HJ, Tanaka E et al (2002) SEN virus: response to interferon alfa and influence on the severity and treatment response of coexistent hepatitis C. Hepatology 35:953–959

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

This study was supported by a grant from the Blood Transfusion Research Center. The authors would like to thank Ghasem Hasan-Nejad for his kind assistance.

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Authors and Affiliations

  1. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Blood Transfusion Organization, Hemmat highway, 146651157, Tehran, Iran

    Hadi Omidi Sani, Zohreh Sharifi & Mahmood Mahmoodian Shooshtari

  2. Department of Microbiology, Faculty of Biological Sciences, University of Shahid Beheshti, G.C., 193954716, Tehran, Iran

    Hadi Omidi Sani & Seyed Masoud Hosseini

Authors
  1. Hadi Omidi Sani
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  2. Zohreh Sharifi
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  3. Seyed Masoud Hosseini
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  4. Mahmood Mahmoodian Shooshtari
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Corresponding author

Correspondence to Zohreh Sharifi.

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Sani, H.O., Sharifi, Z., Hosseini, S.M. et al. SEN virus detection in thalassemic patients infected with hepatitis C virus. Arch Virol 157, 2441–2445 (2012). https://doi.org/10.1007/s00705-012-1443-3

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  • DOI: https://doi.org/10.1007/s00705-012-1443-3

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