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Clinical characteristics of hepatitis B virus infection in middle school students born after the universal infant vaccination program in Shanghai, China

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Abstract

The aim of this study was to investigate the prevalence of hepatitis B surface antigen (HBsAg) and clinical characteristics of middle school students infected with hepatitis B virus (HBV) after initiation of the HBV immunization program in China. A total of 82,156 serum samples were collected from students in 33 junior schools and 25 senior schools. HBsAg was tested by ELISA. Samples from HBsAg-positive students were collected and analyzed for HBV serum markers, alanine aminotransferase (ALT), HBV DNA levels, and HBV genotypes. The overall prevalence of HBsAg was 1.11% in middle school students in Shanghai, China. The prevalence of HBsAg in students born during the immunization program to HBsAg-positive mothers was significantly higher than that in students born during the universal vaccination program (1.47% vs 0.78%, P < 0.01). Only HBV genotypes B and C were found in these infections, and genotype C was the dominant one. Twenty-one (13.0%) of 162 HBsAg-positive students had active hepatitis B, and 18 were hepatitis B e antigen (HBeAg) positive. The universal infant vaccination program has reduced the prevalence of HBsAg significantly. HBeAg-positive hepatitis B, however, needs to be monitored among the students in whom vaccination failed.

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Authors and Affiliations

  1. Laboratory Center, Shanghai TCM-Integrated Hospital, 230 Baoding Road, Shanghai, 200082, China

    Wei-Ling Wang, Zhi-Jun Shu, Li-Xia Zhou & Yan-Rong Zhao

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  1. Wei-Ling Wang
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  2. Zhi-Jun Shu
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  3. Li-Xia Zhou
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  4. Yan-Rong Zhao
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Correspondence to Wei-Ling Wang.

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Wang, WL., Shu, ZJ., Zhou, LX. et al. Clinical characteristics of hepatitis B virus infection in middle school students born after the universal infant vaccination program in Shanghai, China. Arch Virol 157, 901–905 (2012). https://doi.org/10.1007/s00705-012-1251-9

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  • DOI: https://doi.org/10.1007/s00705-012-1251-9

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