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Emergence of norovirus GII-4/2008 variant and recombinant strains in Seoul, Korea

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Abstract

Recently, the emergence of a new NoV GII-4 variant strain every 2 or 3 years has been reported. One hundred seventeen NoV GII strains were detected by RT-PCR in children with AGE between August 2008 and February 2010. In phylogenetic analyses, GII-4 and GII-3 were the most frequently detected strains. The detection rate of the 2008 variant was similar to that of the 2006b variant in the winter seasons of 2009 and 2010. This study shows a changing pattern of a predominant GII-4/2006b variant to the 2008 variant, as well as a novel NoV recombinant strain, GII-6/GII-14, in Korea.

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References

  1. Allen DJ, Gray JJ, Gallimore CI, Xerry J, Iturriza-Gomara M (2008) Analysis of amino acid variation in the P2 domain of the GII-4 norovirus VP1 protein reveals putative variant-specific epitopes. PLoS One 3:e1485

    Article  PubMed  Google Scholar 

  2. Belliot G, Kamel AH, Ambert-Balay K, Estienney M, Pothier P (2010) Evidence of emergence of new GGII.4 norovirus variants from gastroenteritis outbreak survey in France during the 2007 to 2008 and 2008 to 2009 winter seasons. J Clin Microbiol 48:994–998

    Article  PubMed  Google Scholar 

  3. Bruggink LD, Marshall JA (2009) Identification of a novel codon in the norovirus GII.4 polymerase region which acts as a marker of major GII.4 norovirus epidemics. Infect Genet Evol 9:653–655

    Article  CAS  PubMed  Google Scholar 

  4. Bull RA, Tanaka MM, White PA (2007) Norovirus recombination. J Gen Virol 88:3347–3359

    Article  CAS  PubMed  Google Scholar 

  5. Bull RA, Eden JS, Rawlinson WD, White PA (2010) Rapid evolution of pandemic noroviruses of the GII.4 lineage. PLoS Pathog 6:e1000831

    Article  PubMed  Google Scholar 

  6. Campos GS, Moreau VH, Bandeira A, Barberino G, Almeida PF, Amador DM, de Lima MO, Sardi SI (2008) Molecular detection and genetic diversity of norovirus in hospitalized young adults with acute gastroenteritis in Bahia, Brazil. Arch Virol 153:1125–1129

    Article  CAS  PubMed  Google Scholar 

  7. Chhabra P, Walimbe AM, Chitambar SD (2010) Molecular characterization of three intergenotype norovirus GII recombinant strains from Western India. Virus Res 147:242–246

    Article  CAS  PubMed  Google Scholar 

  8. Chung JY, Han TH, Park SH, Kim SW, Hwang ES (2010) Detection of GII-4/2006b variant and recombinant noroviruses in children with acute gastroenteritis, South Korea. J Med Virol 82:146–152

    Article  CAS  PubMed  Google Scholar 

  9. Dey SK, Phan TG, Mizugucia M, Okitsua S, Ushijima H (2010) Novel recombinant norovirus in Japan. Virus Genes 40:362–364

    Article  CAS  PubMed  Google Scholar 

  10. Hansman GS, Natori K, Shirato-Horikoshi H, Ogawa S, Oka T, Katayama K, Tanaka T, Miyoshi T, Sakae K, Kobayashi S, Shinohara M, Uchida K, Sakurai N, Shinozaki K, Okada M, Seto Y, Kamata K, Nagata N, Tanaka K, Miyamura T, Takeda N (2006) Genetic and antigenic diversity among noroviruses. J Gen Virol 87:909–919

    Article  CAS  PubMed  Google Scholar 

  11. Huh JW, Kim WH, Moon SG, Lee JB, Lim YH (2009) Viral etiology and incidence associated with acute gastroenteritis in a 5-year survey in Gyeonggi province, South Korea. J Clin Virol 44:152–156

    Article  PubMed  Google Scholar 

  12. Ike AC, Brockmann SO, Hartelt K, Marschang RE, Contzen M, Oehme RM (2006) Molecular epidemiology of norovirus in outbreaks of gastroenteritis in southwest Germany from 2001 to 2004. J Clin Microbiol 44:1262–1267

    Article  CAS  PubMed  Google Scholar 

  13. Kumar S, Tamura K, Nei M (2004) MEGA3: integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Brief Bioinform 5:150–163

    Article  CAS  PubMed  Google Scholar 

  14. Le VP, Jung YC, Kang KS, Lim IS, Myung SC, Kim WY (2010) Genetic characterization of norovirus GII4.2006b variants from Jeju Island, South Korea. J Med Virol 82:1065–1070

    Article  CAS  PubMed  Google Scholar 

  15. Lindesmith LC, Donaldson EF, Lobue AD, Cannon JL, Zheng DP, Vinje J, Baric RS (2008) Mechanisms of GII.4 norovirus persistence in human populations. PLoS Med 5:e31

    Article  PubMed  Google Scholar 

  16. Lole KS, Bollinger RC, Paranjape RS, Gadkari D, Kulkarni SS, Novak NG, Ingersoll R, Sheppard HW, Ray SC (1999) Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination. J Virol 73:152–160

    CAS  PubMed  Google Scholar 

  17. Lopman B, Vennema H, Kphli E, Pothier P, Sanchez A, Negredo A, Buesa J, Schrier E, Reacher M, Brown D, Gray J, Iturriza M, Gallimore C, Bottiger B, Hedlund KO, Torven M, von Bonsdorff CH, Maunula L, Poljask-Prjiatelj M, Zimsek J, Reuter G, Szucs G, Melegh B, Svensson L, van Duijnhoven Y, Koopmans M (2004) Increase in viral gastroenteritis outbreaks in Europe and epidemic spread of new norovirus variant. Lancet 63:682–688

    Google Scholar 

  18. Nakamura K, Iwai M, Zhang J, Obara M, Horimoto E, Hasegawa S, Kurata T, Takizawa T (2009) Detection of a novel recombinant norovirus from sewage water in Toyama prefecture, Japan. Jpn J Infect Dis 62:394–398

    CAS  PubMed  Google Scholar 

  19. Nayak MK, Balasubramanian G, Sahoo GC, Bhattacharya R, Vinje J, Kobayashi N, Sarkar MC, Bhattacharya MK, Krishnan T (2008) Detection of a novel intergenogroup recombinant norovirus from Kolkata, India. Virology 377:117–123

    Article  CAS  PubMed  Google Scholar 

  20. Park KS, Jeong HS, Baek KA, Lee CG, Park SM, Park JS, Choi YJ, Choi HJ, Cheon DS (2010) Genetic analysis if norovirus GII.4 variants circulating in Korea in 2008. Arch Virol 155:635–641

    Article  CAS  PubMed  Google Scholar 

  21. Phan TG, kaneshi K, Ueda Y, Nakaya S, Nishimura S, Yamamoto A, Sugita K, Takanashi S, Okitsu S, Ushijima H (2007) Genetic heterogeneity, evolution, and recombination in noroviruses. J Med Virol 79:1388–1400

    Article  CAS  PubMed  Google Scholar 

  22. Posada D (2002) Evaluation of methods for detecting recombination from DNA sequences: empirical data. Mol Biol Evol 19:708–717

    CAS  PubMed  Google Scholar 

  23. Siebenga JJ, Vennema H, Renckens B, de Bruin E, van der Veer B, Siezen RJ, Koopmans M (2007) Epochal evolution of GGII.4 norovirus capsid proteins from 1995 to 2006. J Virol 81:9932–9941

    Article  CAS  PubMed  Google Scholar 

  24. Siebenga JJ, Lemey P, Kosakovsky Pond SL, Rambaut A, Vennema H, Koopmans M (2010) Phylodynamic reconstruction reveals norovirus GII.4 epidemic expansions and their molecular determinants. PLoS Pathog 6:e1000884

    Google Scholar 

  25. Vidal R, Roessler P, Solari V, Vollaire J, Jiang X, Matson DO, Mamani N, Prado V, O’Ryan ML (2006) Novel recombinant norovirus causing outbreaks of gastroenteritis in Santiago, Chile. J Clin Microbiol 44:2271–2275

    Article  CAS  PubMed  Google Scholar 

  26. Yan H, Yagyu F, Okitsu S, Nishio O, Ushijima H (2003) Detection of norovirus (GI, GII), Sapovirus and astrovirus in fecal samples using reverse transcription single-round multiplex PCR. J Virol Methods 114:37–44

    Article  CAS  PubMed  Google Scholar 

  27. Yoon JS, Lee SG, Hong SK, Lee SA, Jheong WH, Oh SS, Oh MH, Ko GP, Lee CH, Paik SY (2008) Molecular epidemiology of norovirus infections in children with acute gastroenteritis in South Korea in November 2005 through November 2006. J Clin Microbiol 46:1474–1477

    Article  CAS  PubMed  Google Scholar 

  28. Zheng DP, Ando T, Fankhauser RL, Beard RS, Glass RI, Monroe SS (2006) Norovirus classification and proposed strain nomenclature. Virology 346:312–323

    Article  CAS  PubMed  Google Scholar 

  29. Zheng DP, Widdowson MA, Glass RI, Vinje J (2009) Molecular epidemiology of genogroup II-genotype 4 noroviruses in the United States between 1994 and 2006. J Clin Microbiol 48:168–177

    Article  PubMed  Google Scholar 

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Acknowledgments

This study was partly supported by the research grant (2009) by Inje University.

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Correspondence to Ju-Young Chung.

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T.-H. Han and C.-H. Kim equally contributed for this work.

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Han, TH., Kim, CH., Chung, JY. et al. Emergence of norovirus GII-4/2008 variant and recombinant strains in Seoul, Korea. Arch Virol 156, 323–329 (2011). https://doi.org/10.1007/s00705-010-0844-4

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  • DOI: https://doi.org/10.1007/s00705-010-0844-4

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