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Completion of the full-length genome sequence of human parainfluenza virus types 4A and 4B: sequence analysis of the large protein genes and gene start, intergenic and end sequences

Archives of Virology volume 156, pages 161–166 (2011)Cite this article

Abstract

We have already reported the nucleotide sequences of the NP, P/V, M, F and HN genes of human parainfluenza virus type 4A (hPIV-4A) and type 4B (hPIV-4B). Here, we have determined the sequences of the L protein genes as well as the gene start, intergenic and end sequences, thereby completing the full-length genome sequence of hPIV-4A and 4B. hPIV-4A and 4B have 17,052 and 17,304 nucleotides, respectively. The end sequence of hPIV-4, especially 4B, was extraordinarily long. In a comparison with members of the genus Rubulavirus, the hPIV-4 L proteins were closely related to those of mumps virus (MUV) and hPIV-2, less closely related to those of Menangle virus and Tioman virus, and more distantly related to those of Mapuera virus and porcine rubulavirus.

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Acknowledgments

The present work was supported in part by a grant from Japanese Ministry of Education, Science, Sports and Culture.

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Affiliations

  1. Department of Microbiology, Suzuka University of Medical Science Suzuka, Mie, 510-0293, Japan

    Hiroshi Komada, Eri Hatakeyama, Mai Nakanishi, Shiho Sakue, Chika Joh, Eriko Suzumura, Jun Uematsu & Hidetaka Yamamoto

  2. Department of Microbiology, Mie University Graduate School of Medicine, Tsu, Mie, 514-8507, Japan

    Mitsuo Kawano, Atsuo Uefuji, Masato Tsurudome, Tatsuya Tamaki, Toshifumi Tomioka & Machiko Nishio

  3. Department of Microbiology, College of Life and Health Sciences, Chubu University, Kasugai, Aichi, 487-8501, Japan

    Morihiro Ito & Yasuhiko Ito

  4. Division of Laboratory Animal Resources, National Research Institute for Child Health and Development, Setagaya, Tokyo, 157-8535, Japan

    Hideki Tsumura

  5. Graduate School of Mie Prefectural College of Nursing, Tsu, Mie, 514-0116, Japan

    Myles O’Brien

  6. Department of Applied Bioscience, Faculty of Agriculture, Graduate School of Hokkaido University, Sapporo, Hokkaido, 060-8589, Japan

    Hisanori Bando

Authors
  1. Hiroshi Komada
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  2. Mitsuo Kawano
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  3. Atsuo Uefuji
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  4. Morihiro Ito
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  5. Masato Tsurudome
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  6. Eri Hatakeyama
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  7. Mai Nakanishi
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  8. Shiho Sakue
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  9. Chika Joh
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  10. Eriko Suzumura
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  11. Tatsuya Tamaki
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  12. Toshifumi Tomioka
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  13. Machiko Nishio
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  14. Hideki Tsumura
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  15. Jun Uematsu
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  16. Hidetaka Yamamoto
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  17. Myles O’Brien
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  18. Hisanori Bando
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  19. Yasuhiko Ito
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Corresponding author

Correspondence to Hiroshi Komada.

Additional information

Nucleotide sequence data reported are available in the DDBJ/EMBL/GenBank databases under the accession numbers AB543336 (hPIV-4A) and AB543337 (hPIV-4B). The scheduled release date is July 16, 2010.

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Komada, H., Kawano, M., Uefuji, A. et al. Completion of the full-length genome sequence of human parainfluenza virus types 4A and 4B: sequence analysis of the large protein genes and gene start, intergenic and end sequences. Arch Virol 156, 161–166 (2011). https://doi.org/10.1007/s00705-010-0834-6

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  • DOI: https://doi.org/10.1007/s00705-010-0834-6

Keywords

  • Stop Codon
  • Intergenic Region
  • Newcastle Disease Virus
  • Measle Virus
  • Leader Sequence