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Completion of the full-length genome sequence of human parainfluenza virus types 4A and 4B: sequence analysis of the large protein genes and gene start, intergenic and end sequences

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Abstract

We have already reported the nucleotide sequences of the NP, P/V, M, F and HN genes of human parainfluenza virus type 4A (hPIV-4A) and type 4B (hPIV-4B). Here, we have determined the sequences of the L protein genes as well as the gene start, intergenic and end sequences, thereby completing the full-length genome sequence of hPIV-4A and 4B. hPIV-4A and 4B have 17,052 and 17,304 nucleotides, respectively. The end sequence of hPIV-4, especially 4B, was extraordinarily long. In a comparison with members of the genus Rubulavirus, the hPIV-4 L proteins were closely related to those of mumps virus (MUV) and hPIV-2, less closely related to those of Menangle virus and Tioman virus, and more distantly related to those of Mapuera virus and porcine rubulavirus.

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Acknowledgments

The present work was supported in part by a grant from Japanese Ministry of Education, Science, Sports and Culture.

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Authors and Affiliations

  1. Department of Microbiology, Suzuka University of Medical Science Suzuka, Mie, 510-0293, Japan

    Hiroshi Komada, Eri Hatakeyama, Mai Nakanishi, Shiho Sakue, Chika Joh, Eriko Suzumura, Jun Uematsu & Hidetaka Yamamoto

  2. Department of Microbiology, Mie University Graduate School of Medicine, Tsu, Mie, 514-8507, Japan

    Mitsuo Kawano, Atsuo Uefuji, Masato Tsurudome, Tatsuya Tamaki, Toshifumi Tomioka & Machiko Nishio

  3. Department of Microbiology, College of Life and Health Sciences, Chubu University, Kasugai, Aichi, 487-8501, Japan

    Morihiro Ito & Yasuhiko Ito

  4. Division of Laboratory Animal Resources, National Research Institute for Child Health and Development, Setagaya, Tokyo, 157-8535, Japan

    Hideki Tsumura

  5. Graduate School of Mie Prefectural College of Nursing, Tsu, Mie, 514-0116, Japan

    Myles O’Brien

  6. Department of Applied Bioscience, Faculty of Agriculture, Graduate School of Hokkaido University, Sapporo, Hokkaido, 060-8589, Japan

    Hisanori Bando

Authors
  1. Hiroshi Komada
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  2. Mitsuo Kawano
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  3. Atsuo Uefuji
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  4. Morihiro Ito
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  5. Masato Tsurudome
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  6. Eri Hatakeyama
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  7. Mai Nakanishi
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  8. Shiho Sakue
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  9. Chika Joh
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  10. Eriko Suzumura
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  11. Tatsuya Tamaki
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  12. Toshifumi Tomioka
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  13. Machiko Nishio
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  14. Hideki Tsumura
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  15. Jun Uematsu
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  16. Hidetaka Yamamoto
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  17. Myles O’Brien
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  18. Hisanori Bando
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  19. Yasuhiko Ito
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Corresponding author

Correspondence to Hiroshi Komada.

Additional information

Nucleotide sequence data reported are available in the DDBJ/EMBL/GenBank databases under the accession numbers AB543336 (hPIV-4A) and AB543337 (hPIV-4B). The scheduled release date is July 16, 2010.

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Komada, H., Kawano, M., Uefuji, A. et al. Completion of the full-length genome sequence of human parainfluenza virus types 4A and 4B: sequence analysis of the large protein genes and gene start, intergenic and end sequences. Arch Virol 156, 161–166 (2011). https://doi.org/10.1007/s00705-010-0834-6

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  • DOI: https://doi.org/10.1007/s00705-010-0834-6

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