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The emergence of genotypes 3 and 4 hepatitis E virus in swine and humans: a phylogenetic perspective

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Abstract

To investigate whether there is any phylogenetic evidence to support the hypothesis that swine is the natural host of HEV genotypes 3 and 4, Bayesian analysis of 80 full-length genomic sequences of HEV was performed. The results showed that the strains of genotypes 3 and 4 from swine are paraphyletic with regard to strains of human origin, which are thus phylogenetically nested among the swine strains. Recognition of HEV genotypes 3 and 4 as viruses from swine or swine HEV can provide an evolutionary explanation to the observation of cross-species infection by genotypes 3 and 4 HEV.

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Acknowledgments

The work was supported by the Award of Excellence (Excellensbidrag) provided to SB by the Swedish University of Agricultural Sciences (SLU). NW wishes to acknowledge support from the Academy of Finland.

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Authors and Affiliations

  1. Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, 751 89, Uppsala, Sweden

    Hongyan Xia & Sándor Belák

  2. Joint R&D Division in Virology, The National Veterinary Institute, Swedish University of Agricultural Sciences, 751 89, Uppsala, Sweden

    Hongyan Xia, Sándor Belák & Lihong Liu

  3. Laboratory of Genetics, Department of Biology, University of Turku, 20014, Turku, Finland

    Niklas Wahlberg

  4. College of Veterinary Medicine, Department of Biomedical Sciences and Pathobiology, Center for Molecular Medicine and Infectious Diseases, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA

    X. J. Meng

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  1. Hongyan Xia
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  2. Niklas Wahlberg
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  3. Sándor Belák
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  4. X. J. Meng
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  5. Lihong Liu
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Correspondence to Lihong Liu.

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Xia, H., Wahlberg, N., Belák, S. et al. The emergence of genotypes 3 and 4 hepatitis E virus in swine and humans: a phylogenetic perspective. Arch Virol 156, 121–124 (2011). https://doi.org/10.1007/s00705-010-0818-6

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  • DOI: https://doi.org/10.1007/s00705-010-0818-6

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