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Genetic evolution of equine influenza viruses isolated in China

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Abstract

China experienced an outbreak of equine influenza during 2007–2008. Meanwhile, its neighbor countries, such as Mongolia, India and Japan, have also been affected by various influenza virus strains in each country. Phylogenetic analysis showed that the newly emerging Chinese strains belong to Florida sublineage clade 2, as well as the Indian strain Jammu-Katra/6/08 and the Mongolian strain Mongolia/1/08. All of these strains were derived from European strains of this clade, such as the Newmarket/1/07 and Cheshire/1/07 strains, but these were not related to Japanese strains isolated around the same time (Florida sublineage clade 1) or to Chinese strains isolated in the 1990s (European lineage). Some unique amino acid changes were found in the antigenic sites in Asian strains of Florida sublineage clade 2. Moreover, the loss of a glycosylation site was found in the Liaoning/9/08 strain. From these studies, we have determined that equine influenza viruses in China have evolved with some new characteristics during recent years, and this emphasizes the importance of continued equine influenza virus surveillance in China.

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Acknowledgments

We thank Dr. Yanbin Li and Mr. Xuefeng Li for excellent technical assistance with EIV diagnostics. This work was supported by the Natural Science Foundation of Heilongjiang province in China (no. ZD200812).

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Authors and Affiliations

  1. Division of Livestock Infectious Diseases, National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150001, People’s Republic of China

    Ting Qi, Wei Guo, Wen-Qiang Huang, Hong-Mei Li, Li-Ping Zhao, Ling-Li Dai, Na He, Xiao-Fang Hao & Wen-Hua Xiang

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  1. Ting Qi
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  2. Wei Guo
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  3. Wen-Qiang Huang
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  4. Hong-Mei Li
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  6. Ling-Li Dai
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  7. Na He
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  8. Xiao-Fang Hao
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  9. Wen-Hua Xiang
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Correspondence to Wen-Hua Xiang.

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T. Qi and W. Guo contributed equally to this work.

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Qi, T., Guo, W., Huang, WQ. et al. Genetic evolution of equine influenza viruses isolated in China. Arch Virol 155, 1425–1432 (2010). https://doi.org/10.1007/s00705-010-0724-y

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