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Quantitative analysis of fecal sapovirus shedding: identification of nucleotide substitutions in the capsid protein during prolonged excretion

Archives of Virology volume 154, pages 689–693 (2009)Cite this article

Abstract

Sapovirus (SaV) is an important pathogen causing gastroenteritis in humans. Quantitative analysis of the viral loads in feces collected from two SaV outbreaks was performed. Our results showed that SaV excretion generally decreased to an undetectable level in 2 weeks; however, some individuals excrete SaV in feces at high concentrations for 2–4 weeks after the onset of illness. In addition, we identified for the first time nucleotide changes in the capsid region during prolonged excretion.

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Acknowledgments

This work was supported in part by a Grant for Food Safety from the Ministry of Health, Labour, and Welfare of Japan.

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Affiliations

  1. Miyazaki Prefectural Institute for Public Health and Environment, Miyazaki, Japan

    Akira Iwakiri, Hidenari Ganmyo & Seigo Yamamoto

  2. Miyazaki Prefecture Nobeoka Health Office, Miyazaki, Japan

    Kayoko Otao & Mieko Mikasa

  3. Miyazaki Prefecture Nichinan Health Office, Miyazaki, Japan

    Sigeko Kizoe

  4. Department of Virology II, National Institute of Infectious Diseases, Gakuen 4-7-1, Musashi-murayama, Tokyo, 208-0011, Japan

    Kazuhiko Katayama, Takaji Wakita, Naokazu Takeda & Tomoichiro Oka

Authors
  1. Akira Iwakiri
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  2. Hidenari Ganmyo
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  3. Seigo Yamamoto
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  4. Kayoko Otao
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  5. Mieko Mikasa
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  6. Sigeko Kizoe
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  7. Kazuhiko Katayama
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  8. Takaji Wakita
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  9. Naokazu Takeda
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  10. Tomoichiro Oka
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Correspondence to Tomoichiro Oka.

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Iwakiri, A., Ganmyo, H., Yamamoto, S. et al. Quantitative analysis of fecal sapovirus shedding: identification of nucleotide substitutions in the capsid protein during prolonged excretion. Arch Virol 154, 689–693 (2009). https://doi.org/10.1007/s00705-009-0358-0

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  • DOI: https://doi.org/10.1007/s00705-009-0358-0

Keywords

  • Viral Load
  • Nucleotide Change
  • Fecal Specimen
  • Prolonged Excretion
  • Sapovirus