Abstract
The ICP34.5 gene from HSV-2 strain 333 was cloned and, when expressed in Vero cells, enhanced the efficiency and extent of glycoprotein processing of glycoprotein C (gC1), a representative viral glycoprotein, during infection with HSV-1 SP7. The ICP34.5 from HSV-1 SP7 limits the extent and efficiency of viral glycoprotein processing. The ability of the HSV-2 ICP34.5 protein to enhance the efficiency and extent of HSV-1 SP7 glycoprotein processing indicates that modulation of viral glycoprotein processing is also a property of the HSV-2 ICP34.5 protein.
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References
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Chatterjee, S., Wang, J.W., Cismowski, M.J. et al. HSV-2 ICP34.5 protein modulates herpes simplex virus glycoprotein processing. Arch Virol 154, 661–663 (2009). https://doi.org/10.1007/s00705-009-0341-9
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DOI: https://doi.org/10.1007/s00705-009-0341-9