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The distribution of HBV genotypes and clinical significance in familial clustering in an infected population with unfavorable prognosis

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Abstract

Using a nested-PCR genotyping system, we analyzed the viral genotypes in HBV-infected patients from HBV clustering infection families (CIFs), as compared with HBV infected patients without familial infection history. The patients in the CIF group showed significantly increased prevalence of genotype C infection, while genotype B was absent. Additionally, in the genotype C carriers younger than 50 years old, the prevalence of HCC and LC were significantly increased in CIF compared to the control. We found that HBeAg-positive HBV genotype C carriers are prone to develop end-stage liver diseases earlier than those infected by genotype B.

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Abbreviations

CIF:

Clustering infection family

ASC:

Asymptomatic HBV carriers

CHB:

Chronic hepatitis B

LC:

Liver cirrhosis

HCC:

Hepatocellular carcinoma

HBeAg:

Hepatitis B e antigen

anti-HBeAg:

Antibody against hepatitis B e antigen

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Acknowledgments

This study was supported by a grant from the National Natural Science Foundation of China (No. 30671862).

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Authors and Affiliations

  1. Department of Infectious Diseases, The First Affiliated Hospital of Xi’an JiaoTong University School of Medicine, 710061, Xi’an, Shaanxi Province, China

    Jinfeng Liu, Tianyan Chen, Yuan Yang, Ke Wang, Yingli He, Qian Yang, Feng Ye, Yan Jin, Ting Qiu, Shumei Lin, Min Liu & Yingren Zhao

  2. Central Hospital of Xi’an, 710061, Xi’an, Shaanxi Province, China

    Yongqin Li

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  1. Jinfeng Liu
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  2. Yongqin Li
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  3. Tianyan Chen
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  4. Yuan Yang
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  5. Ke Wang
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  12. Min Liu
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  13. Yingren Zhao
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Correspondence to Yingren Zhao.

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Liu, J., Li, Y., Chen, T. et al. The distribution of HBV genotypes and clinical significance in familial clustering in an infected population with unfavorable prognosis. Arch Virol 153, 2157–2161 (2008). https://doi.org/10.1007/s00705-008-0239-y

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  • DOI: https://doi.org/10.1007/s00705-008-0239-y

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