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Polymorphisms of interferons and their receptors in the genetics of severe RSV-associated diseases

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Abstract

Because of their important role in the pathophysiology of severe RSV infection, IFNs represent an ideal group of candidate genes for determining RSV disease severity. We studied 14 polymorphisms within 7 genes involved in IFNs signalling. Our study populations consisted of 156 infants with severe RSV infection and 296 healthy control children. None of the genes showed association with severe RSV infection in children. Thus, despite the involvement of different IFNs in the pathophysiology of RSV infection, genetic variants in IFNG and related genes might not alter the risk for the development of severe RSV-associated diseases.

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Acknowledgments

This project was supported by a grant from the Deutsche Forschungsgemeinschaft to Andrea Heinzmann (DFG HE 3123/3-2) as well as by a research grant from Abbott. We particularly wish to thank all participating children and their families.

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Authors and Affiliations

  1. Centre for Pediatrics and Adolescent Medicine, University of Freiburg, Mathildenstrasse 1, 79106, Freiburg, Germany

    Beena Mailaparambil, Johannes Jochum, Johannes Forster, Jessica Heinze, Marcus Krueger & Andrea Heinzmann

  2. St Josefs Hospital, Sautier Str. 1, 79104, Freiburg, Germany

    Johannes Forster

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  1. Beena Mailaparambil
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  2. Johannes Jochum
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  3. Johannes Forster
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  4. Jessica Heinze
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  5. Marcus Krueger
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  6. Andrea Heinzmann
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Correspondence to Andrea Heinzmann.

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Mailaparambil, B., Jochum, J., Forster, J. et al. Polymorphisms of interferons and their receptors in the genetics of severe RSV-associated diseases. Arch Virol 153, 2133–2137 (2008). https://doi.org/10.1007/s00705-008-0232-5

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  • DOI: https://doi.org/10.1007/s00705-008-0232-5

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