Abstract
The viral lytic gene BZLF1 triggers replication of the Epstein–Barr virus (EBV), which is commonly found in nasopharyngeal carcinoma (NPC). Here, RT-PCR revealed five new BZLF1 variants in 8 of 12 NPC and 4 of 12 non-NPC nasopharyngeal biopsies from an NPC-endemic area in southern China. The deduced peptide sequence of the dominant BZLF1 variant differed by 11 amino acids from that of the prototypical strain B95.8 (V01555). Anti-ZEBRA antibody levels were higher in NPC than that in non-NPC patients (P < 0.001). These findings demonstrated a dominant BZLF1 variant in southern Chinese EBV-associated NPC and non-NPC patients.
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The authors thank Drs. C.-B. Wang, K. Edmondson and A.P. Smith for editorial revision of this manuscript.
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Ji, KM., Li, CL., Meng, G. et al. New BZLF1 sequence variations in EBV-associated undifferentiated nasopharyngeal carcinoma in southern China. Arch Virol 153, 1949–1953 (2008). https://doi.org/10.1007/s00705-008-0195-6
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DOI: https://doi.org/10.1007/s00705-008-0195-6