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Long terminal repeats of porcine endogenous retroviruses in Sus scrofa

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Summary

Using PCR, sequencing, and bioinformatic approaches with the genomic DNAs of Korean pigs (domestic, wild, and hybrid with Yorkshire), twelve solitary PERV long terminal repeat elements were identified and analyzed. Structure analysis of the LTR elements indicated that they have different repeat sequences in the U3 region. The PERV-A6-KWP1 and -KWP2 elements bear seven and eight 39-bp repeats, respectively. The R region of the PERV LTR elements was highly conserved in pig and mouse genomes, suggesting that they seem to have originated from a common exogenous viral element and then evolved independently throughout the course of mammalian evolution.

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Authors and Affiliations

  1. Division of Biological Sciences, College of Natural Sciences, Pusan National University, Busan, Republic of Korea

    J.-W. Huh, H.-S. Ha, Y.-N. Noh, J.-M. Yi, W.-H. Lee & H.-S. Kim

  2. Department of Animal Science, College of Life Sciences, Pusan National University, Miryang, Republic of Korea

    B.-W. Cho

  3. PBBRC, Interdisciplinary Research Program of Bioinformatics, College of Natural Sciences, Pusan National University, Busan, Republic of Korea

    D.-S. Kim & H.-S. Kim

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  1. J.-W. Huh
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  2. B.-W. Cho
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  3. D.-S. Kim
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  4. H.-S. Ha
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  5. Y.-N. Noh
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  6. J.-M. Yi
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  7. W.-H. Lee
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  8. H.-S. Kim
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The first and second authors contributed equally to this work.

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Huh, JW., Cho, BW., Kim, DS. et al. Long terminal repeats of porcine endogenous retroviruses in Sus scrofa . Arch Virol 152, 2271–2276 (2007). https://doi.org/10.1007/s00705-007-1049-3

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  • DOI: https://doi.org/10.1007/s00705-007-1049-3

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