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Analysis of HIV-1 CRF07_BC gag p6 sequences indicating novel deletions in the central region of p6

Archives of Virology volume 152, pages 1553–1558 (2007)Cite this article

Summary

We amplified gag sequences from 66 individuals infected with HIV-1 CRF07_BC during 2003–2005 in the Xinjiang region of China. A novel deletion of 7aa (including a KELY motif) in the central region of the CRF07_BC gag p6 domain was detected, which has not been reported in other HIV-1 subtypes. Further deletions of up to 13aa (including KQE and KELY motifs) was also found in this domain, representing the biggest natural deletion up to now. Moreover, the CD4+ count and viral load level indicated that 1–13aa deletions in CRF07_BC gag p6 do not have a significant effect on viral replication and fitness.

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Affiliations

  1. State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, P.R. China

    Y. H. Song, Z. F. Meng, H. Xing, Y. H. Ruan, X. P. Li, R. L. Xin, P. F. Ma, H. Peng & Y. Shao

  2. Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, P.R. China

    Y. H. Song & Y. Shao

  3. Graduate School of the Chinese Academy of Sciences, Beijing, P.R. China

    Y. H. Song

Authors
  1. Y. H. Song
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  2. Z. F. Meng
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  3. H. Xing
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  4. Y. H. Ruan
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  5. X. P. Li
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  6. R. L. Xin
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  7. P. F. Ma
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  8. H. Peng
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  9. Y. Shao
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Additional information

YanHui Song and ZheFeng Meng contributed equally to this paper.

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Song, Y., Meng, Z., Xing, H. et al. Analysis of HIV-1 CRF07_BC gag p6 sequences indicating novel deletions in the central region of p6. Arch Virol 152, 1553–1558 (2007). https://doi.org/10.1007/s00705-007-0973-6

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  • DOI: https://doi.org/10.1007/s00705-007-0973-6

Keywords

  • Viral Load Level
  • Deletion Pattern
  • PTAP Motif
  • Public Health Laboratory Service
  • HXB2 Sequence