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Comparison of the immunogenicity of recombinant VP2 and VP3 of infectious pancreatic necrosis virus and marine birnavirus

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Summary.

Recombinant proteins of truncated viral protein-2 (VP2) (aa 79-359) and VP3 of infectious pancreatic necrosis virus (IPNV) and marine birnavirus (MABV) were expressed in E. coli and their immunogenicities in fish were investigated. The recombinant proteins from IPNV were used to immunize rainbow trout and those from MABV to immunize flounder. The sera from the immunized fishes were assayed for antibody by ELISA and a neutralization test. Both the recombinant VP2 and VP3 produced antibodies in fish but the VP3 antibody titers were higher than that of the VP2 of IPNV and MABV. These results indicate that the recombinant VP3 is more immunogenic than the re-combinant VP2.

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Authors and Affiliations

  1. Department of Biological Sciences, University of Ulsan, Ulsan, Korea

    C. H. Moon & J. W. Park

  2. Pathology Division, National Fisheries Research and Development Institute, Kijang, Pusan, Korea

    J. W. Do, S. J. Cha, J.-D. Bang & M. A. Park

  3. Gyeongbuk Research Center for Freshwater Fish, Gyeongbuk, Korea

    D. J. Yoo

  4. Department of Genetic Engineering and RNA Inc., Kyung Hee University, Yongin-gun, Kyungki-do, Korea

    J. M. Lee, H. G. Kim & D. K. Chung

Authors
  1. C. H. Moon
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  2. J. W. Do
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  3. S. J. Cha
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  4. J.-D. Bang
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  5. M. A. Park
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  6. D. J. Yoo
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  7. J. M. Lee
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  8. H. G. Kim
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  9. D. K. Chung
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  10. J. W. Park
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Moon, C., Do, J., Cha, S. et al. Comparison of the immunogenicity of recombinant VP2 and VP3 of infectious pancreatic necrosis virus and marine birnavirus. Arch Virol 149, 2059–2068 (2004). https://doi.org/10.1007/s00705-004-0339-2

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  • DOI: https://doi.org/10.1007/s00705-004-0339-2

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