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Olfactory function in idiopathic Parkinson's disease (IPD): results from cross-sectional studies in IPD patients and long-term follow-up of de-novo IPD patients

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Summary.

Olfactory loss is a prominent symptom in idiopathic Parkinson's disease (IPD). Experiment 1 re-investigated the diagnostic value of psychophysical testing in the differentiation between idiopathic Parkinson disease (IPD) from non-IPD; 50 consecutive PS patients participated. In Experiment 2 five de-novo patients received 3 olfactory tests spread over a period of appoximately one year. Nineteen IPD patients were anosmic, and 18 were hyposmic. All but one patient with MSA and PSP had mild/moderate hyposmia. Normosmia was found in CBD/misdiagnosed PS/psychogenic movement disorder. In Experiment 2, one of the de-novo patients was normosmic, 3 hyposmic, and 1 anosmic. Follow up investigations indicated decreased olfactory function in 3 patients while it improved in one. The normosmic patient retained olfactory abilities. This patient failed to respond to pharmacological treatment. In summary, olfactory tests differentiate IPD from non-IPD. Furthermore, tests of olfactory function may also be of interest in investigations related to treatment of PS.

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Authors and Affiliations

  1. Departments of Neurology and, , , , , , DE

    A. Müller & H. Reichmann

  2.  Otorhinolaryngology, University of Dresden Medical School, Dresden, Federal Republic of Germany, , , , , , DE

    T. Hummel

  3.  School of Social Sciences & Liberal Studies, Charles Sturt University – Mitchell, Bathurst NSW, Australia, , , , , , AU

    A. Livermore

Authors
  1. A. Müller
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  2. H. Reichmann
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  3. A. Livermore
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  4. T. Hummel
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Received December 10, 2001; accepted January 23, 2002

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Müller, A., Reichmann, H., Livermore, A. et al. Olfactory function in idiopathic Parkinson's disease (IPD): results from cross-sectional studies in IPD patients and long-term follow-up of de-novo IPD patients. J Neural Transm 109, 805–811 (2002). https://doi.org/10.1007/s007020200067

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  • DOI: https://doi.org/10.1007/s007020200067

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