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Macaque animal model for HIV-induced neurological disease

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Summary.

The pathogenesis of HIV-induced neurological disorders is still incompletely understood. Since many aspects of this disease are difficult to explore in humans, animal models are necessary to fill the gaps in our knowledge. Based on the high concordance with the human system, the SIV-infection of macaques currently provides the best animal model to study pathogenesis, therapy and prevention of HIV-infection. In this review, important features of the CNS-infection in this model are outlined. Recent virological, immunological, neurophysiological and neurochemical findings obtained with this animal model are presented and key factors in the development of neurological disease are identified.

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Authors and Affiliations

  1.  Institut für Virologie und Immunbiologie,, , , , , , DE

    S. Sopper, E. Koutsilieri, C. Scheller & V. ter Meulen

  2.  Klinische Neurochemie, Klinik und Poliklinik für Psychiatrie and Psychotherapie, and, , , , , , DE

    P. Riederer

  3.  Institut für Pathologie, Universität Würzburg, Federal Republic of Germany, , , , , , DE

    S. Czub

Authors
  1. S. Sopper
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  2. E. Koutsilieri
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  3. C. Scheller
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  4. S. Czub
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  5. P. Riederer
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  6. V. ter Meulen
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Additional information

Received January 21, 2002; accepted February 22, 2002

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Sopper, S., Koutsilieri, E., Scheller, C. et al. Macaque animal model for HIV-induced neurological disease. J Neural Transm 109, 747–766 (2002). https://doi.org/10.1007/s007020200062

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  • DOI: https://doi.org/10.1007/s007020200062

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