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Skin function and skin disorders in Parkinson’s disease

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Cutaneous symptoms (seborrhoea and hyperhidrosis) in Parkinson’s disease were investigated. In 70 treated patients with Parkinson’s disease and 22 control subjects, non-invasive bioengineering methods (sebumetry, corneometry, pH) were carried out on the forehead, sternum and forearm. In addition, concomitant dermatoses and medication were recorded. 18.6% of the patients had seborrhoea on the forehead (τ220µg/cm2), 51.4% showed normal sebum values (100–220 µg/cm2) and 30% a sebostasis (<100µg/cm2). Males has significantly higher sebum values than females. No relationship between the seborrhoea and the therapy for Morbus Parkinson was found. Patients with hyperhidrosis (n=36) had significantly lower pH values (p<0.05) on the forehead than those without hyperhidrosis. 22 patients (31.9%) reported a cold/hot flush and a further 13 (18.8%) had clinical rosacea. Seborrhoea is rare in treated Parkinsonian patients but hyperhidrosis is frequently found. Furthermore, a particular lack of vasostability (flush) appears to be an autonomie dysregulation in the skin related to Morbus Parkinson, which has not been studied to any extent to date.

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Fischer, M., Gemende, I., Marsch, W.C. et al. Skin function and skin disorders in Parkinson’s disease. J Neural Transm 108, 205–213 (2001).

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