Summary.
Sodium azide (20 mg/kg sc), given for a maximum of 3 days to rats, significantly decreased the α-tocopherol concentrations in the cortex on day 2 and in the striatum on day 3. In these brain regions the oxidized glutathione values showed 30 to 36% (statistically not significant) elevation on day 3. Reduced glutathione levels were not altered. The observations suggest an important role for α-tocopherol in the defense against azide induced free radicals probably including NO and lipid peroxide radicals.
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Received February 8, 2000; accepted October 17, 2000
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Vécsei, L., Tajti, J., Klivényi, P. et al. Sodium azide treatment decreases striatal and cortical concentrations of α-tocopherol in rats. J Neural Transm 108, 273–278 (2001). https://doi.org/10.1007/s007020170072
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DOI: https://doi.org/10.1007/s007020170072