Summary.
Sodium azide (20 mg/kg sc), given for a maximum of 3 days to rats, significantly decreased the α-tocopherol concentrations in the cortex on day 2 and in the striatum on day 3. In these brain regions the oxidized glutathione values showed 30 to 36% (statistically not significant) elevation on day 3. Reduced glutathione levels were not altered. The observations suggest an important role for α-tocopherol in the defense against azide induced free radicals probably including NO and lipid peroxide radicals.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received February 8, 2000; accepted October 17, 2000
Rights and permissions
About this article
Cite this article
Vécsei, L., Tajti, J., Klivényi, P. et al. Sodium azide treatment decreases striatal and cortical concentrations of α-tocopherol in rats. J Neural Transm 108, 273–278 (2001). https://doi.org/10.1007/s007020170072
Issue Date:
DOI: https://doi.org/10.1007/s007020170072