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Scyllo-inositol in post-mortem brain of bipolar, unipolar and schizophrenic patients

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Summary.

Inositol levels measured in postmortem brain of unipolar, bipolar and schizophrenic patients, suicide victims and normal controls showed no difference in scyllo-inositol levels in frontal or occipital cortex between any of the groups. We could not replicate previous reports of low myo-inositol levels in the frontal cortex of unipolar, bipolar and schizophrenic patients and suicide victims. There was no correlation between myo-inositol levels and estimated chlorpromazine equivalents in neuroleptic-treated subjects, and no effect of chronic haloperidol treatment on rat brain myo-inositol levels.

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Authors and Affiliations

  1. Stanley Center for Bipolar Research, Ben-Gurion University of the Negev, Beersheva, Israel, , , , , , IL

    J. Shapiro, R. H. Belmaker & G. Agam

  2. Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheva, Israel, , , , , , IL

    A. Biegon & A. Seker

Authors
  1. J. Shapiro
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  2. R. H. Belmaker
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  3. A. Biegon
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  4. A. Seker
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  5. G. Agam
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Additional information

Received July 23, 1999; accepted January 18, 2000

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Shapiro, J., Belmaker, R., Biegon, A. et al. Scyllo-inositol in post-mortem brain of bipolar, unipolar and schizophrenic patients. J Neural Transm 107, 603–607 (2000). https://doi.org/10.1007/s007020070081

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  • DOI: https://doi.org/10.1007/s007020070081

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