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No evidence for an association between the Glu298Asp polymorphism of the NOS3 gene and Alzheimer's disease

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Summary.

Recently a significant association of a missense mutation (Glu298Asp) of the endothelial nitric oxide synthase (NOS3) gene with late-onset Alzheimer's disease (LOAD) was reported. We tried to replicate this finding in a Japanese sample of 121 patients with LOAD, 51 with early-onset AD (EOAD), and 165 medical controls. However, the genotype and allelic distributions for the Glu298Asp polymorphism were similar for these three groups, suggesting that the Glu298Asp polymorphism of the NOS3 gene has no relevance to the development of AD in Japanese.

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Authors and Affiliations

  1. Department of Psychiatry, Teikyo University School of Medicine, Tokyo,, , , , ,

    H. Kunugi, A. Akahane & S. Nanko

  2. Department of Neurology, Jichi Medical School, Omiya,, , , , ,

    A. Ueki & M. Otsuka

  3. Department of Psychiatry, Tokyo Metropolitan Toshima Hospital, Tokyo,, , , , ,

    K. Isse

  4. Department of Psychiatry, Tokyo Metropolitan Geriatric Hospital, Tokyo,, , , , ,

    H. Hirasawa

  5. Department of Internal Medicine, Teikyo University School of Medicine, Tokyo,, , , , ,

    N. Kato

  6. Department of Laboratory Medicine, and, , , , ,

    T. Nabika

  7. Department of Internal Medicine, Shimane Medical University, Shimane, Japan, , , , , , JP

    S. Kobayashi

Authors
  1. H. Kunugi
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  2. A. Akahane
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  3. A. Ueki
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  4. M. Otsuka
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  5. K. Isse
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  6. H. Hirasawa
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  7. N. Kato
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  8. T. Nabika
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  9. S. Kobayashi
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  10. S. Nanko
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Additional information

Received March 20, 2000; accepted May 22, 2000

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Kunugi, H., Akahane, A., Ueki, A. et al. No evidence for an association between the Glu298Asp polymorphism of the NOS3 gene and Alzheimer's disease. J Neural Transm 107, 1081–1084 (2000). https://doi.org/10.1007/s007020070053

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  • DOI: https://doi.org/10.1007/s007020070053

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