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Low CSF soluble interleukin 2 receptor levels in acute depression

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Summary.

Thirteen patients with DSM-III-R diagnosis of either major depression or bipolar I depression participated in the study. The control group consisted of 10 subjects evaluated for headache or suspected meningitis, none of whom were found to suffer from any organic disease. CSF was withdrawn from all subjects for the measurement of soluble interleukin 2 receptor (sIL-2R). CSF sIL-2R levels were found to be lower in patients as compared to controls (df = 1, 20; F = 84; p < 0.000001).

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Authors and Affiliations

  1. Beersheva Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel, , , , , , IL

    J. Levine

  2. Western Psychiatric Institute & Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA, , , , , , US

    K. R. N. Chengappa & S. M. Antelman

  3. Abrabanel Mental Health Center, Bat Yam,, , , , ,

    Y. Barak

  4. Volfson Hospital, Neurology Department, Holon, and, , , , ,

    A. Rapoport

  5. Immunology Laboratory for Tumor Diagnosis, Oncology Department, Hadassah University Hospital, Jerusalem, Israel, , , , , , IL

    V. Barak

Authors
  1. J. Levine
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  2. Y. Barak
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  3. K. R. N. Chengappa
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  4. A. Rapoport
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  5. S. M. Antelman
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  6. V. Barak
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Additional information

Received May 12, 1999; accepted May 26, 1999

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Levine, J., Barak, Y., Chengappa, K. et al. Low CSF soluble interleukin 2 receptor levels in acute depression. J Neural Transm 106, 1011–1015 (1999). https://doi.org/10.1007/s007020050219

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  • DOI: https://doi.org/10.1007/s007020050219

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