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An overnight switch to ropinirole therapy in patients with Parkinson's disease

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Summary.

Patients with Parkinson's disease (n = 68) switched from per-golide or bromocriptine to ropinirole overnight (dose equivalence ratios – 1 : 6 and 10 : 6, respectively). The activities of daily living score for the Unified Parkinson's Disease Rating Scale (UPDRS) was significantly improved 4 weeks after the bromocriptine–ropinirole switch. All other UPDRS scores, including that for the side-effect component, were not significantly different after either switch. Overnight switching may be a safe therapeutic approach that may reduce hospitalisation and related socio-economic costs.

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Authors and Affiliations

  1. Parkinson Institute Milan, Istituti Clinici di Perfezionamento, Milan, Italy, , , , , , IT

    M. Canesi, A. Antonini, C. B. Mariani, S. Tesei, A. L. Zecchinelli, M. Barichella & G. Pezzoli

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  1. M. Canesi
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  2. A. Antonini
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  3. C. B. Mariani
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  4. S. Tesei
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  5. A. L. Zecchinelli
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  6. M. Barichella
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  7. G. Pezzoli
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Additional information

Received January 28, 1999; accepted June 30, 1999

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Canesi, M., Antonini, A., Mariani, C. et al. An overnight switch to ropinirole therapy in patients with Parkinson's disease. J Neural Transm 106, 925–929 (1999). https://doi.org/10.1007/s007020050212

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  • DOI: https://doi.org/10.1007/s007020050212

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