Skip to main content
SpringerLink
Log in

The activity of Catechol-O-Methyltransferase in parkinsonian patients with "on-off fluctuations"

  • Published:
Journal of Neural Transmission Aims and scope Submit manuscript

Summary.

Motor fluctuations complicate therapy in Parkinson's disease (PD). The mechanisms responsible for motor fluctuations such as the on-off type, are poorly understood. Differences of activity of various enzymes, such as Catechol-O-Methyltransferase (COMT, E.C.2.1.1.6.) may influence the appearance of motor fluctuations and the quantity of metabolic products of levodopa. Aim of this study was to compare erythrocyte COMT-activity in Parkinsonian patients without and with motor fluctuations from the on-off type. No significant differences in COMT-activity appeared in both groups. We conclude that activity differences in COMT-activity do not contribute to the appearance of motor fluctuations in Parkinson's disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Department of Neurology, University of Bochum, St. Josef Hospital, Bochum, Federal Republic of Germany, , , , , , DE

    D. Woitalla, R. Karwasz, Th. Müller, H. Przuntek & W. Kuhn

Authors
  1. D. Woitalla
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Karwasz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Th. Müller
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. Przuntek
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. W. Kuhn
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Received August 4, 1999; accepted August 18, 1999

Rights and permissions

Reprints and permissions

About this article

Cite this article

Woitalla, D., Karwasz, R., Müller, T. et al. The activity of Catechol-O-Methyltransferase in parkinsonian patients with "on-off fluctuations". J Neural Transm 107, 105–111 (2000). https://doi.org/10.1007/s007020050009

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s007020050009

Search

Navigation