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Investigation of the nonmotor symptoms in patients with STN-DBS therapy in comparison with those without STN-DBS

  • Neurology and Preclinical Neurological Studies - Original Article
  • Published:
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Abstract

The impact of STN-DBS on NMS remains rather as an underestimated topic. Besides, the significance of NMSs in QOL indexes of PD subjects with STN-DBS is unknown. We primarily aimed to evaluate the NMSs and their significance in QOL indexes in PD subjects comparatively with and without STN-DBS therapy. We enrolled all consecutive PD subjects with and without STN-DBS who applied to our movement disorders outpatient clinics between January/2023 and September/2023. We performed comprehensive assessments of the motor and nonmotor features including the clinical scales of Movement Disorder Society-sponsored revision of the MDS-UPDRS, NMSS, HAM-A, HAM-D, and the PDQ-39. Overall, 48 PD subjects with STN-DBS and 161 without STN-DBS treatment were included. The comparative analyses revealed that the sub-scores of the MDS-UPDRS-2, -3 and -4 were higher in the STN-DBS group. However, the MDS-UDPRS-1 and the total scores of the NMSS were similar between groups. Among eight subitems of the NMSS, only, the sub scores of the mood/cognition and the gastrointestinal tract differed. Remarkably, the significant correlations between the scores of the QOL and the NMSS scores in the STN-DBS (–) group, did not persist within the STN-DBS group. Remarkably, the correlations between the NMSS and PQQ-39 disappeared for most of the sub scores within the STN-DBS group. We found indirect evidence regarding the benefit of STN-DBS therapy on NMSs in our cross-sectional study. Besides, we found weaker impact of NMSs in QOL indexes in PD subjects with STN-DBS therapy.

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Data availability

The data that support the findings of this study are available from the corresponding author, [author initials], upon reasonable request.

Abbreviations

NMS:

Non-motor symptoms

QOL:

Quality-of-life

STN-DBS:

Subthalamic nucleus deep brain stimulation

PD:

Parkinson’s disease

MDS-UPDRS:

Unified Parkinson’s Disease Rating Scale

NMSS:

Nonmotor symptoms scale

HAM-A:

Hamilton Anxiety Rating Scale

HAM-D:

Hamilton Depression Rating Scale

PDQ-39:

Parkinson’s Disease Questionnaire

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The authors declare that there are no additional disclosures to report.

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Authors and Affiliations

  1. Neurology Clinic, Etlik City Hospital, Varlık, Halil Sezai Erkut Street. No:5, 06170 Yenimahalle, 06110, Ankara, Turkey

    Halil Onder & Selcuk Comoglu

Authors
  1. Halil Onder
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  2. Selcuk Comoglu
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Contributions

(1) Research project: A. Conception, B. Organisation, C. Execution; (2) Statistical Analysis: A. Design, B. Execution, C. Review and Critique; (3) Manuscript Preparation: A. Writing of the first draft, B. Review and Critique. HO: 1A, 1B, 1C, 3A, 3B; SSC; 1A, 3B.

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Correspondence to Halil Onder.

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The ethical approval has been obtained from the local committee of the Etlik City Hospital. The informed consent form has been obtained from all the patients. We confirm that we have read the Journal’s position on issues involved in ethical publication and affirm that this work is consistent with those guidelines.

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Onder, H., Comoglu, S. Investigation of the nonmotor symptoms in patients with STN-DBS therapy in comparison with those without STN-DBS. J Neural Transm (2024). https://doi.org/10.1007/s00702-024-02778-y

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